Sökning: "GLP-1"

Visar resultat 6 - 10 av 87 avhandlingar innehållade ordet GLP-1.

  1. 6. Incretin Hormone Secretion - Studies in Human Subjects

    Författare :Ola Lindgren; Lund Medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; insulin; obesity; GLP-1; GIP; incretin;

    Sammanfattning : Several different hormones are released from the intestine following a meal. In this thesis we have focused on the so called incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). LÄS MER

  3. 7. Studies of cAMP and Ca2+ signaling in pancreatic islet cells

    Författare :Hongyan Shuai; Anders Tengholm; Erik Gylfe; Sebastian Barg; Albert Salehi; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pancreatic islet; insulin; glucagon; somatostatin; pancreatic polypeptide; exendin- 9-39 ; GLP-1; GIP; ATP; adenosine; cAMP; Ca2 ; β-cell; α-cell; δ-cell; PP-cell;

    Sammanfattning : The blood glucose-lowering and -elevating hormones insulin and glucagon are released from the pancreatic islet β- and α-cells, respectively. The intracellular messengers Ca2+ and cAMP have central roles in controlling the secretion of both hormones, but the underlying mechanisms are incompletely understood. LÄS MER

  4. 8. Central actions of glucagon-like peptide-1 on food intake and reward: Novel neurological targets and sex divergent effects

    Författare :Jennifer E. Richard; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glucagon-like peptide-1; Food reward; Food intake; GLP-1; Sex differences;

    Sammanfattning : Obesity is one of the biggest health risks of our society; however, treatment options are sparse and often result in suboptimal weight-loss. The glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) agonist liraglutide was recently approved for treatment of obesity in the US. LÄS MER

  5. 9. Gut peptides in gastrointestinal motility and mucosal permeability

    Författare :Md. Abdul Halim; Webb Dominic-Luc; Per M Hellström; Lars Fändriks; Uppsala universitet; []
    Nyckelord :Gut regulatory peptides; Neuropeptides; Gastrointestinal mucosal permeability; Gastrointestinal motility; GLP-1; NPS; ROSE-010;

    Sammanfattning : Gut regulatory peptides, such as neuropeptides and incretins, play important roles in hunger, satiety and gastrointestinal motility, and possibly mucosal permeability. Many peptides secreted by myenteric nerves that regulate motor control are also produced in mucosal epithelial cells. LÄS MER

  7. 10. Physiology and Pathophysiology of Hormone Secretion from lslets of Langerhans

    Författare :Samuel Acreman; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Islet; diabetes; glucagon; insulin; somatostatin; incretin; pancreas; hypoglycaemia; tetraspanin; GLP-1; endoplasmic reticulum;

    Sammanfattning : Diabetes is a metabolic disorder stemming from the improper regulation of blood glucose levels by hormones secreted by pancreatic islets of Langerhans. Paper I describes the mechanism by which glucose can regulate glucagon secretion, independent of membrane potential, from pancreatic α-cells, via modulation of endoplasmic reticulum Ca2+ handling. LÄS MER