Sökning: "GLP-1"

Visar resultat 21 - 25 av 87 avhandlingar innehållade ordet GLP-1.

  1. 21. On the Impact of Bariatric Surgery on Glucose Homeostasis

    Författare :Niclas Abrahamsson; Britt Eden Engström; Jan Eriksson; Magnus Sundbom; Neil Gerard Docherty; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hypoglycaemia; Gastric Bypass surgery; Biliopancreatic diversion with duodenal switch DS ; NT-ProBNP; Continuous glucose measuring system CGMS ; GLP-1-analog; glucose variability; MAGE; CONGA; counter regulation; incretin; Heart Rate Variability; Endocrinology and Diabetology; Endokrinologi och Diabetologi;

    Sammanfattning : Obesity has grown to epidemic proportions, and in lack of efficient life-style and medical treatments, the bariatric surgeries are performed in rising numbers. The most common surgery is the Gastric Bypass (GBP) surgery, with the Biliopancreatic diversion with duodenal switch (DS) as an option for the most extreme cases with a BMI>50 kg/m2. LÄS MER

  3. 22. Strategies to improve outcome after islet transplantation using the GLP-1 receptor agonist, extendin-4

    Författare :Amit Sharma; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Transplantation of pancreatic islets into the liver via the portal vein has emerged as a treatment option for patients with type I diabetes mellitus. However, loss of functional beta cell mass during isolation and following implantation is a major obstacle in obtaining good long-term results. LÄS MER

  4. 23. Development of nuclear medicine methods for gastric and small bowel motility : effects of GLP-1 on gastric emptying

    Författare :Per Grybäck; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Gastric emptying; ghrelin; glucagon-like peptide-1; 99mTc-HIDA; obesity; radionuclide investigation; small bowel transit.;

    Sammanfattning : The diagnosis of functional disorders of the gastrointestinal (GI) tract requires techniques being both sufficiently sensitive to detect disturbances of the normal physiology and low-invasive enough not to interfere with the properties being studied. The purpose was to set up nuclear medicine methods for assessment of upper GI tract motility and study the effect of glucagon-like peptide-1 (GLP-1) on gastric emptying. LÄS MER

  5. 24. Metabolic and endocrine effects of SGLT2 inhibition

    Författare :Per Lundkvist; Jan Eriksson; Lars Lind; Maria J Pereira; Michael Alvarsson; Uppsala universitet; []
    Nyckelord :SGLT2 inhibition; GLP-1 receptor agonism; DPP4 inhibition; NAFLD; prediabetes; type 2 diabetes; obesity; metabolic syndrome; glucagon.; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Obesity and type 2 diabetes (T2D) are two growing global health problems with similar comorbidity profiles. SGLT2 inhibitors (SGLT2i) improve blood glucose control and can relieve both T2D and obesity, as well as their associated health problems such as hypertension, kidney failure, and cardiovascular disease. LÄS MER

  7. 25. GLP-1 secretion and signaling in patients with aneurysmal enlargement of the thoracic aorta : a potential contributor to reduced prevalence of aneurysm in diabetes

    Författare :Stelia Ntika; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : An aortic aneurysm is a localized dilation of the artery, greater than 50% of the normal size. It is the result of a weakening of the aortic wall, and untreated or unrecognized aortic aneurysms may be fatal due to massive internal bleeding, as a result of dissection or rupture of the aneurysm. LÄS MER