Sökning: "GLP-1"
Visar resultat 11 - 15 av 87 avhandlingar innehållade ordet GLP-1.
11. Roux-en-Y gastric bypass - clinical outcome and mechanisms of action
Sammanfattning : Roux-en-Y gastric bypass (gastric bypass) is an effective surgical technique for treating morbid obesity. The objective of this thesis is to increase knowledge of long-term outcomes of gastric bypass surgery and to elucidate some of the associated mechanisms of action. LÄS MER
12. Regulation of glucagon secretion from pancreatic alpha cells
Sammanfattning : Glucagon secreted by pancreatic α-cells plays an important role in the regulation of blood glucose. In this thesis, different techniques such as electrophysiology, immunohistochemistry and hormone secretion assay were combined to explore the mechanisms by which glucagon secretion is regulated. LÄS MER
13. Pathophysiology and treatment of defective insulin secretion in diabetes
Sammanfattning : Defective insulin secretion is a central feature in diabetes mellitus and results from reduced pancreatic beta-cell mass as well as aberrant beta-cell function. The pathophysiology of diabetes is incompletely known, but a strong hereditary component is suggested. LÄS MER
14. Childhood Obesity and Islet Function
Sammanfattning : The prevalence of childhood obesity and Type 2 Diabetes Mellitus (T2DM) has increased during recent decades. T2DM is accompanied with functional changes in the islets of Langerhans, which can be identified early in the pathogenesis. LÄS MER
15. On the Generation of cAMP Oscillations and Regulation of the Ca2+ Store-operated Pathway in Pancreatic Islet α- and β-cells
Sammanfattning : Insulin and glucagon are released in pulses from pancreatic β- and α-cells, respectively. Both cell types are electrically excitable, and elevation of the cytoplasmic Ca2+ concentration ([Ca2+]i) due to depolarization with voltage-dependent entry of the cation is the main trigger of hormone secretion. LÄS MER