Sökning: "Francisella tularensis"

Visar resultat 1 - 5 av 23 avhandlingar innehållade orden Francisella tularensis.

  1. 1. Cutaneous resistance against Francisella tularensis

    Författare :Stephan Stenmark; Umeå universitet.; [2004]
    Nyckelord :tularemia; Francisella tularensis; skin; protection; cytokines; T-cells; B-cells; specific antibodies; Infectious Diseases; infektionssjukdomar;

    Sammanfattning : Francisella tularensis, the causative agent of tularemia, is a potent pathogen in humans and other mammals. The ulceroglandular form of the disease is the most common expression in humans with a clinical picture characterized by a skin ulcer, enlarged regional lymph nodes and fever. LÄS MER

  2. 2. The oxidative stress response of Francisella tularensis

    Detta är en avhandling från Umeå : Umeå Universitet

    Författare :Marie Honn; Umeå universitet.; [2016]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Francisella tularensis; FupA; MglA; OxyR; ROS; oxidative stress; molekylärbiologi; Molecular Biology;

    Sammanfattning : Francisella tularensis is capable of infecting numerous cell types, including professional phagocytes. Upon phagocytosis, F. tularensis resides within the phagosome before escaping into the cytosol to replicate. Phagocytes constitute a hostile environment rich in ROS, which are employed as a means of killing pathogens. LÄS MER

  3. 3. Identification of new virulence factors in Francisella tularensis

    Detta är en avhandling från Umeå : Institutionen för Molekylärbiologi, Umeå universitet

    Författare :Anna-Lena Forslund; Umeå universitet.; [2010]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Francisella tularensis; regulation; virulence; Hfq; DsbA; type IV pili; membrane; NATURAL SCIENCES Biology Cell and molecular biology Molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Francisella tularensis, the causative agent of tularemia, is a highly virulent bacterium with an infection dose of less than ten bacteria. The ability of a pathogen to cause infection relies on different virulence mechanisms, but in Francisella tularensis relatively few virulence factors are known. Two F. LÄS MER

  4. 4. The genetic composition and diversity of Francisella tularensis

    Detta är en avhandling från Umeå : Klinisk mikrobiologi

    Författare :Pär Larsson; Umeå universitet.; [2007]
    Nyckelord :Microbiology; tularemia; genotyping; evolution; microarray; genome sequencing; virulence; genome reduction; Mikrobiologi; Francisella tularensis; klinisk bakteriologi; Clinical Bacteriology;

    Sammanfattning : Francisella tularensis is the causative agent of the debilitating, sometimes fatal zoonotic disease tularemia. To date, little information has been available on the genetic makeup of this pathogen, its evolution, and the genetic differences which characterize subspecific lineages. These are the main areas addressed in this thesis. LÄS MER

  5. 5. Mechanisms of the intracellular survival of Francisella tularensis

    Detta är en avhandling från Umeå : Umeå universitet

    Författare :Linda Tancred; Umeå universitet.; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Francisella tularensis; Igl; MglA; J774; IFN-γ; RNS; ROS; phagosome; MEDICINE Microbiology; immunology; infectious diseases Microbiology Clinical bacteriology; MEDICIN Mikrobiologi; immunologi; infektionssjukdomar Mikrobiologi Klinisk bakteriologi; mikrobiologi; Microbiology;

    Sammanfattning : Francisella tularensis is a gram-negative, highly virulent, intracellular bacterium which causes the zoonotic disease tularemia. The subspecies tularensis and holarctica are clinically important, and the former is the more virulent. The intracellular lifestyle of F. LÄS MER