Sökning: "Drosophila development"

Visar resultat 11 - 15 av 112 avhandlingar innehållade orden Drosophila development.

  1. 11. Investigating the function of the Receptor Tyrosine Kinase ALK during Drosophila melanogaster development

    Författare :Christina Lorén; Mike Taylor; Umeå universitet; []
    Nyckelord :DAlk; receptor tyrosine kinase; Jeb; visceral muscle fusion; ERK; Drosophila; endoderm; molecular cell biology; molekylär cellbiologi;

    Sammanfattning : The Drosophila melanogaster gene Anaplastic Lymphoma Kinase (DAlk) is homologous to mammalian Alk, which is a member of the Alk/Ltk family of receptor tyrosine kinases (RTKs). In humans the t(2;5) translocation involving the Alk locus encodes an active form of Alk that is the causative agent in Non-Hodgkin’s Lymphoma (Morris et al., 1994). LÄS MER

  3. 12. The role of polysaccharide modifications during Drosophila development

    Författare :Florian Lüders; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ontogeni; growth animal ; embryologi; Development biology; Decapentaplegic; Hedgehog; Wingless; Sulfation; Pipe; Glycosaminoglycan; Glycosyltransferase; ontogeny; embryology; Utvecklingsbiologi;

    Sammanfattning : Glucosides attached to proteins and lipids have been shown to modulate the activity of signal transduction pathways regulating growth and patterning processes during animal development. In particular, O-linked glycans such as glycosaminoglycans (GAGs) have been implicated in modulation of growth factor signaling pathways. LÄS MER

  4. 13. Regulators of chromatin and transcription in Drosophila

    Författare :Filip Crona; Mattias Mannervik; Fernando Azorin; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Transcription; chromatin; co-regulators; CBP; lysine demethylase; KDM4A; Brakeless; Drosophila; utvecklingsbiologi; Developmental Biology;

    Sammanfattning : Development of multicellular organisms is achieved by organized temporal and spatial patterns of gene expression leading to cell differentiation. Chromatin regulators control how the DNA is utilized by altering access of proteins to DNA and thereby function as co-factors in transcription. LÄS MER

  5. 14. Deciphering the Alk signaling pathway in Drosophila

    Författare :Fredrik Hugosson; Ruth H. Palmer; Osamu Shimmi; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Drosophila; Alk; RTK; visceral mesoderm; signal transduction; growth factor; transcription factor; molekylärbiologi; Molecular Biology;

    Sammanfattning : In Drosophila melanogaster the visceral mesoderm (VM) develops during embryogenesis in a process where myoblasts become specified to generate two distinct cell types, the founder cells (FCs) and the fusion competent myoblasts (FCMs) that consequently fuses. The cell specification is dependent on cell signaling mediated by the receptor tyrosine kinase (RTK) Anaplastic lymphoma kinase (Alk) and its ligand Jelly belly (Jeb), how this further sets up different identity programs that drive myoblasts to differentiate into FCs and FCMs is still not well understood. LÄS MER

  7. 15. Small non-coding RNA in early fly development : plasticity, interactions and improved bioinformatic tools

    Författare :Lovisa Örkenby; Anita Öst; Rashmi Ramesh; Daniel Nätt; Nicola Iovino; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Drosophila; Maternal-to-zygotic transition; sncRNA; miRNA; piRNA; Embryogenesis; Zygotic gene activation;

    Sammanfattning : At fertilization, the male and female pronuclei undergo a transformation from germline to pluripotency as they fuse, marking the beginning of Drosophila embryogenesis. As the parental contributions decrease, the zygote takes control of its genome in a process called the maternal-to-zygotic transition (MZT). LÄS MER