Sökning: "DNA strand breaks"

Visar resultat 1 - 5 av 93 avhandlingar innehållade orden DNA strand breaks.

  1. 1. Recognition and signaling of DNA double-strand breaks in human cells

    Författare :Ismail Hassan Ismail; Göteborgs universitet; []
    Nyckelord :DNA-PK; DNA double-strand break; DSB; DNA single-strand break; SSB; DNA damage; ionizing radiation; IR; DNA repair; calicheamicin kappa1; ATM; hydrogen peroxide; H2AX; radiotherapy; radiosensitizer; flow cytometry;

    Sammanfattning : DNA double-strand breaks (DSBs) are the most toxic type of DNA damage. Fortunately, our cells have highly conserved pathways that detect and repair DSBs. Defects in DSB signaling and DSB repair pathways result in genomic instability that predisposes for cancer development. LÄS MER

  3. 2. Role of Non-Homologous End-Joining in Repair of Radiation-Induced DNA Double-Strand Breaks

    Författare :Karin Karlsson; Bo Stenerlöw; Jörgen Carlsson; Thomas Helleday; Uppsala universitet; []
    Nyckelord :Molecular biology; DNA damage; DNA repair; DSB; NHEJ; DNA-PK; ionising radiation; high-LET; heat-labile sites; PFGE; Molekylärbiologi;

    Sammanfattning : Efficient and correct repair of DNA damage, especially DNA double-strand breaks (DSBs), is vital for the survival of individual cells and organisms. Defects in the DNA repair may lead to cell death or genomic instability and development of cancer. LÄS MER

  4. 3. Replication Dynamics in the DNA Damage Response

    Författare :Petra Groth; Thomas Helleday; Geroge Iliakis; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; DNA damage; DNA replication; homologous recombination; DNA double strand-breaks; ionizing radiation; alkylating agents; NATURAL SCIENCES; NATURVETENSKAP; Genetics; Genetik; molekylärgenetik; Molecular Genetics;

    Sammanfattning : Faithful DNA replication is essential and the induction of replication stress may have profound effects on genomic integrity. This is demonstrated by the formation of DNA double strand breaks (DSBs), considered to be the most toxic DNA lesions, at stalled replication forks. LÄS MER

  5. 4. Ionising radiation and DNA double strand breaks in human cells : formation, intracellular protection and consequences

    Författare :Jonas Nygren; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cells; radiation effects; DNA; Cytologi;

    Sammanfattning : .... LÄS MER

  7. 5. Evolving the Methodology for Detection of Primary DNA Damage : Development, adaptation and assessment of the single cell gel electrophoresis (comet) assay

    Författare :Erik Bivehed; Björn Hellman; Hanna Karlsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Comet assay; DNA damage; DNA strand breaks; Flash-comet; Genotoxicity; In vitro; Single cell gel electrophoresis; Polymerase assisted DNA damage assay PADDA ; TK6 cells; UCDAS; U937 cells; Toxikologi; Toxicology; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Deoxyribonucleic acid (DNA) is one of the most important molecules in nature. It is the fundamental carrier of evolutionary information and constitutes the genetic blueprint of all living organisms. Being the sole source of information, it is vital for the cell to transmit the correct genetic information from generation to generation. LÄS MER