Sökning: "DCS"

Visar resultat 1 - 5 av 178 avhandlingar innehållade ordet DCS.

  1. 1. Biophysical Studies of Apolipoprotein A-IM and a Partitioning study

    Författare :Malin Suurkuusk; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Apolipoprotein A-IMilano; Apolipoprotein A-I; Lipoprotein; Lipid; Microcalorimetry; DCS; Denaturation; Guanidine Hydrochloride; Physics; Fysik; Chemistry; Kemi;

    Sammanfattning : The major part of this thesis deals with the similarities and differences in some biophysical properties of apolipoprotein A-I (apo A-I) and the molecular variant apolipoprotein A-IMilano (apo A-IM), and the influence on lipid binding. A model compound partitioning study has also been performed. LÄS MER

  3. 2. Tolerance and Immunity: Opposite Outcomes of Microbial Antigen Stimulation

    Författare :Lena Eroukhmanoff; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TLR2; Tolerance; quinoline-3-carboxamide; Anergy; Foxp3; iNOS; IFN-β; CD4 splenic DCs;

    Sammanfattning : The immune system is remarkable in many ways. It exerts immunity to defend us from foreign pathogens, while it is also responsible for maintaining tolerance to avoid autoimmune diseases and allergy. This thesis includes three separate papers concerning both tolerance and immunity. LÄS MER

  4. 3. Improvement of adoptive T-cell therapy for Cancer

    Författare :Chuan Jin; Magnus Essand; Ola Winqvist; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CAR T-cell therapy; AEP expansion protocol; scaffold matrix attachment region; non-integrating lentivirus; H. pylori Neutrophil-activating protein; allogeneic DCs; Klinisk immunologi; Clinical Immunology;

    Sammanfattning : Cancer immunotherapy has recently made remarkable clinical progress. Adoptive transfer of T-cells engineered with a chimeric antigen receptor (CAR) against CD19 has been successful in treatment of B-cell leukemia. LÄS MER

  5. 4. Cytokine-modulated dendritic cell immunotherapy in autoimmune diseases

    Författare :Sanjaya Bandara Adikari; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Autoimmunity is the result of failure of self-tolerance processes. When the immune system fails to differentiate self from foreign, the effector mechanisms are directed towards the individual s own tissues, and pathological autoimmune disease results. LÄS MER

  7. 5. Immunological properties of dendritic cells in HIV-1 infection

    Författare :Karin Loré; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Dendritic cells; HIV-1; Cytokines; Chemokines; Co-stimulatory molecules; Apoptotic bodies; Lymphoid tissue;

    Sammanfattning : Dendritic cells (DCs) capture antigens for intracellular processing to form MHC-peptide complexes involved in the generation of antigen specific T cell responses. After encountering microbes, DCs migrate from the periphery to the regional lymph nodes. LÄS MER