Sökning: "PDGF-C"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet PDGF-C.

  1. 1. Functions of PDGF-A and -C. Essential ligands for the PDGF alpha receptor

    Detta är en avhandling från Göteborg

    Författare :Hans Boström; Göteborgs universitet.; Gothenburg University.; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; platelet-derived growth factor; PDGF-A; PDGF-C; PDGF alpha receptor; extracellular retention; gene targeting; mouse development; epithelial-mesenchymal interaction; lung; alveolar formation; spina bifida; gastrointestinal villus;

    Sammanfattning : Altered protein kinase activity is a contributing factor in many diseases including most formsof human malignancies, and there is reason to believe that protein kinases will prove to be majordrug targets in the treatment of cancer. Protein kinases mediate most of the signal transduction ineukaryotic cells, regulating cellular events such as transcription, metabolism, proliferation,cytoskeletal rearrangement, migration, differentiation and apoptosis. LÄS MER

  2. 2. Biological activities of novel platelet-derived growth factors, PDGF-C and PDGF-D

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Cell and Molecular Biology

    Författare :Annica Pontén; Karolinska Institutet.; Karolinska Institutet.; [2004]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Platelet-derived growth factors (PDGFs) belong to the PDGF/VEGF (vascular endothelial growth factor) family of growth factors. Members of this family share a common structural feature, a conserved PDGF/VEGF homology domain, containing eight invariant cysteine residues. LÄS MER

  3. 3. On vascular endothelial growth factor B and platelet-derived growth factor C : two members of the VEGF/PDGF family of growth factors

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Cell and Molecular Biology

    Författare :Karin Aase; Karolinska Institutet.; Karolinska Institutet.; [2001]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Vascular endothelial growth factors (VEGFs), platelet-derived growth factors (PDGFs) and their receptors are important for normal development. They have also been implicated in many pathological conditions. VEGFs have been shown to play an important role in the development of both blood and lymphatic vessels. LÄS MER

  4. 4. Studies of VEGF-B and novel PDGFs in tumorigenesis and angiogenesis

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Cell and Molecular Biology

    Författare :Hong Li; Karolinska Institutet.; Karolinska Institutet.; [2004]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The family of VEGF/PDGF growth factors and their receptors are important regulators of tumorigenesis and angiogenesis. VEGFs have been shown to play important roles in development of both blood and lymphatic vessels by effect on endothelia cells. LÄS MER

  5. 5. Proteolytic activation and biological functions of the novel PDGFs

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Cell and Molecular Biology

    Författare :Linda Fredriksson; Karolinska Institutet.; Karolinska Institutet.; [2006]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The platelet-derived growth factors (PDGFs) and their cell surface receptors regulate growth and migration of connective tissue cells of both the vascular network and other organ systems. They are known to be important for normal development and processes, such as wound healing and angiogenesis, but have also been implicated in many pathological conditions, such as malignancies and fibrotic disease. LÄS MER