Sökning: "Clinical"

Visar resultat 1 - 5 av 3109 avhandlingar innehållade ordet Clinical.

  1. 1. In Vitro Drug Sensitivity and Apoptosis in Chronic Lymphocytic Leukemia

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Maria Norberg; Uppsala universitet.; [2010]
    Nyckelord :MEDICIN; MEDICINE; MEDICIN; MEDICINE; MEDICIN; MEDICINE; MEDICIN; MEDICINE; MEDICIN; MEDICINE; chronic lymphocytic leukemia; in vitro drug sensitivity; apoptosis; prognostic markers; Medical Science; Medicinsk vetenskap; Clinical Genetics; Klinisk genetik; Molecular Genetics; Molekylär genetik; Medicinsk genetik; Medical Genetics; Molekylär medicin; Molecular Medicine;

    Sammanfattning : Chronic lymphocytic leukemia (CLL) is a heterogeneous malignancy displaying varying clinical outcome, where molecular markers today can divide patients into prognostic subgroups. Despite the introduction of new agents for treatment, remissions are usually not sustained in CLL and resistance towards treatment can partly be explained by aberrant apoptosis. LÄS MER

  3. 2. Aspects of surgical treatment of morbid obesity : Clinical studies

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Agneta Westling; Uppsala universitet.; [2001]
    Nyckelord :MEDICIN; MEDICINE; Surgery; obesity surgey; silicone adjustable gastric banding; band erosion; revision to RYGBP; laparoscopic RYGBP; deep venous thrombosis; depp venous insufficiency; Kirurgi; kirurgi; Surgery;

    Sammanfattning : Common methods used for surgical treatment of morbid obesity are silicone adjustable gastric banding (SAGB), vertical banded gastroplasty (VBG) and Roux-en-Y gastric bypass (RYGBP). The role of laparoscopy in complex bariatric procedures such as RYGBP is unclear. LÄS MER

  4. 3. Assessment of Novel Molecular Prognostic Markers in Chronic Lymphocytic Leukemia

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Mohamed Arifin Bin Kaderi; Uppsala universitet.; [2010]
    Nyckelord :MEDICIN; MEDICINE; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN; MEDICINE; MEDICIN; MEDICINE; TVÄRVETENSKAPLIGA FORSKNINGSOMRÅDEN; INTERDISCIPLINARY RESEARCH AREAS; MEDICIN; MEDICINE; MEDICIN; MEDICINE; chronic lymphocytic leukemia; prognostic markers; single nucleotide polymorphisms; RNA-based markers; Clinical Genetics; klinisk genetik; molekylär medicin genetik och patologi ; Molecular Medicine; Oncology; onkologi; Medicine; medicin; medicinsk genetik; Medical Genetics;

    Sammanfattning : The clinical course of chronic lymphocytic leukemia (CLL) is highly heterogeneous, which has prompted the search for biomarkers that can predict prognosis in this disease. The IGHV gene mutation status and certain genomic aberrations have been identified as reliable prognostic markers of clinical outcome for this disorder. LÄS MER

  5. 4. Molecular Genetic Analysis in B-cell Lymphomas : A Focus on the p53 Pathway and p16INK4a

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Norafiza Zainuddin; Uppsala universitet.; [2010]
    Nyckelord :MEDICIN; MEDICINE; MEDICIN; MEDICINE; MEDICIN; MEDICINE; MEDICIN; MEDICINE; Diffuse large B-cell lymphoma; chronic lymphocytic leukemia; TP53 mutation; MDM2 SNP309; codon 72 polymorphism; p16INK4a methylation; Clinical Genetics; Klinisk genetik; Medicinsk genetik; Medical Genetics; Molecular Genetics; Molekylär genetik; Oncology; Onkologi; Patologi; Pathology;

    Sammanfattning : The presence of TP53 mutations has been associated with inferior outcome in diffuse large B-cell lymphoma (DLBCL) and chronic lymphocytic leukemia (CLL). In DLBCL, the impact of the TP53 codon 72 polymorphism and MDM2 SNP309 has not been clearly elucidated, whereas MDM2 SNP309 was suggested as a poor-prognostic marker in CLL. LÄS MER

  7. 5. Familial amyloidosis with polyneuropathy : studies of genetic factors modifying the phenotype of the disease

    Detta är en avhandling från Umeå : Umeå university

    Författare :Malin Olsson; Umeå universitet.; Umeå universitet.; [2010]
    Nyckelord :MEDICIN; MEDICINE; MEDICIN; MEDICINE; Familial amyloid polyneuropathy; Amyloidosis; Transthyretin; Allele Frequency; Mitochondria; parent-of-origin; MicroRNA; Single Nucleotide Polymorphism; 3 Untranslated Regions genetics; genetik; Genetics; klinisk genetik; Clinical Genetics; Medicine; medicin;

    Sammanfattning : Background. Familial Amyloidosis with Polyneuropathy (FAP) is an autosomal dominantly inherited systemic amyloid disease. The disease is caused by mutations in the transthyretin (TTR) gene, where close to 100 different amyloidogenic mutations have been identified. LÄS MER