Sökning: "Chromatographic analysis"

Visar resultat 16 - 20 av 112 avhandlingar innehållade orden Chromatographic analysis.

  1. 16. Multivariate spectroscopic methods for the analysis of solutions

    Författare :Kent Wiberg; Sven Jacobsson; Lars Nørgaard; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemometrics; UV-Vis spectroscopy; Multivariate calibration; Lidocaine; Identity; Content; PLS; SIMCA; Non-column; Diode array UV spectroscopy; DAD; Control sample; High Capacity Analysis HCA ; Fluorescence spectroscopy; Albumin; Immunoglobulin G; HPLC-DAD; Prilocaine; Peak purity determination; PCA; PARAFAC; Partial separation; Curve resolution; Analytical chemistry; Analytisk kemi;

    Sammanfattning : In this thesis some multivariate spectroscopic methods for the analysis of solutions are proposed. Spectroscopy and multivariate data analysis form a powerful combination for obtaining both quantitative and qualitative information and it is shown how spectroscopic techniques in combination with chemometric data evaluation can be used to obtain rapid, simple and efficient analytical methods. LÄS MER

  3. 17. Analysis of PAHs and their transformations products in contaminated soil and remedial processes

    Författare :Staffan Lundstedt; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Environmental chemistry; polycyclic aromatic hydrocarbons; PAHs; degredation; transformation; formation; accumulation; oxidation products; metabolites; oxogenated polycyclic aromatic hydrocarbons; oxy-PAHs; soil; gasworks; remediation; bioremediation; bioslurry; wood-rotting fungi; Fenton´s reagent; avaliability; bioavaliability; chemical analysis; extraction; pressurized liquid extraction; PLE; accelerated solvent extraction; ASE; Miljökemi; Environmental chemistry; Miljökemi; analytisk kemi; Analytical Chemistry;

    Sammanfattning : Soil that is heavily contaminated with polycyclic aromatic hydrocarbons (PAHs) is often found at the sites of former gasworks and wood-impregnation plants. Since PAHs are toxic these sites represent a hazard to human health and the environment, and therefore they need to be treated, preferably by a method that destroys the contaminants, and thus eliminates the problem permanently. LÄS MER

  4. 18. Development of LC-MS/MS Methods for the Analysis of Chiral and Achiral Pharmaceuticals and Metabolites in Aqueous Environmental Matrices

    Författare :Victoria K.H. Barclay; Curt Pettersson; Monika Johansson; Niklas Tyrefors; Mohamed Abdel-Rehim; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Environmental water matrices; chiral separation; LC-MS MS; trace analysis; method development; active pharmaceutical ingredients; metabolites; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

    Sammanfattning : This thesis describes the development of liquid chromatography tandem mass spectrometry (LC-MS/MS) methods for the trace analysis of active pharmaceutical ingredients (APIs) and their metabolites in aqueous environmental matrices. The research was focused on the development of chiral LC-MS/MS methods for the analysis of fluoxetine and metoprolol, as well as their chiral metabolites in environmental water samples. LÄS MER

  5. 19. New tools for sample preparation and instrumental analysis of dioxins in environmental samples

    Författare :Lan Do; Peter Haglund; Staffan Lundstedt; Eric Reiner; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; PCDD Fs; dioxins; pressurized liquid extraction; PLE; selective SPLE; modular M-PLE; soil; sediment; sludge; gas chromatography; new stationary phases; multivariate data analysis; selectivity; interaction; Environmental Science; miljövetenskap;

    Sammanfattning : Polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs), two groups of structurally related chlorinated aromatic hydrocarbons, are of high concern due to their global distribution and extreme toxicity. Since they occur at very low levels, their analysis is complex, challenging and hence there is a need for efficient, reliable and rapid alternative analytical methods. LÄS MER

  7. 20. From achiral to chiral analysis of citalopram

    Författare :Björn Carlsson; Yngve Bergqvist; Linköpings universitet; []
    Nyckelord :depression; noradrenaline; dopamine; serotonin; citalopram; selective serotonin-reuptake inhibitor SSRI ; high-performance liquid chromatography HPLC ; therapeutic drug monitoring TDM ; enantioselective separation; MEDICINE; MEDICIN;

    Sammanfattning : Within the field of depression the “monoamine hypothesis” has been the leading theory to explain the biological basis of depression. This theory proposes that the biological basis of depression is due to a deficiency in one or more of three key neurotransmitter systems, namely noradrenaline, dopamine and serotonin which are thought to mediate the therapeutic actions of virtually every known antidepressant agent. LÄS MER