Sökning: "Carbopalladation"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet Carbopalladation.

1. 1. Palladium(II)-Catalyzed Addition Reactions : Synthesis of Aryl Amidines and Aryl Ketones

   Författare :Jonas Rydfjord; Mats Larhed; Adriaan Minnaard; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Palladium; Catalysis; Palladium II catalysis; Synthesis; Addition Reactions; Cyanamide; Amidine; Aryl Amidine; Nitrile; Ketone; Aryl Ketone; Carbopalladation; Continuous-flow; Continuous flow; Microwave heating; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : Palladium-catalyzed reactions have become one of the most important tools in modern organic chemistry due to its ability to catalyze the formation of new carbon-carbon bonds.The aim of the work presented in this thesis was to develop new palladium(II)-catalyzed addition reactions. LÄS MER

3. 2. Synthesis of Indole Alkaloids and Development of New Methodology

   Författare :Anita Hoang; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; total synthesis; indole alkaloids; Domino reactions; vicinal quaternary stereocenters; quaternary stereocenter; indoline synthesis; communesin alkaloid; perophoramidine; dehaloperophoramidine; akuammiline alkaloids; strictamine; intramolecular Heck reaction; domino carbopalladation carbonylation; indoline alkaloids;

   Sammanfattning : This thesis describes our efforts towards the total synthesis of natural products and the development of a newmethodology to afford a synthetically important scaffold.Chapter 2 outlines our efforts towards the total synthesis of a marine natural product, perophoramidine as wellas our completed synthesis of dehaloperophoramidine. LÄS MER

4. 3. New Methods for the Synthesis of Vicinal Stereocenters : Palladium-Catalyzed Domino Reactions and Asymmetric Transfer Hydrogenation

   Författare :Brinton Seashore-Ludlow; Somfai Peter; Kevin Booker-Milburn; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; asymmetric synthesis; domino reactions; palladium-catalyzed reactions; oxindoles; amino alcohols;

   Sammanfattning : In this thesis the synthesis of vicinal stereocenters is investigated in two distinct contexts, namely the construction of 3,3-disubstituted oxindoles and the synthesis of b-hydroxy-a-amino acids. Both scaffolds are prevalent in a range of natural products and biologically relevant compounds and, therefore, methods for their synthesis are of great import. LÄS MER

5. 4. Stereoselective Nucleophilic Additions to Aldehydes and Development of New Methodology in Organic Synthesis

   Författare :Tessie Borg; Olof Ramström; Siméon Arseniyadis; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : This thesis is divided into four separate parts with nucleophilic addition to aldehydes as the common feature in three of them.The first part deals with the investigation of the stereochemical induction and elucidation of the factors that dictate the p-facial selectivities in Mukaiyama aldol addition to a- and a,b-heteroatom substituted aldehydes. LÄS MER

7. 5. Natural Product Synthesis and Development of Novel Reaction Methodology

   Författare :Jakob Danielsson; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; perophoramidine; communesin; quaternary stereocenter; Diels-Alder; 1; 2-asymmetric induction; polar Felkin-Anh; Cornforth-Evans; Mukaiyama aldol; 3-dipolar cycloaddition; azomethine ylide; 2-amino alcohol; anti-α-amino-β-hydroxy ester;

   Sammanfattning : This thesis deals with the development of new reaction methodology for stereoselective synthesis, as well as total synthesis of natural products and investigations of the stereochemical outcome in the Mukaiyama aldol reaction. Chapter 2 describes efforts made towards the total synthesis of the oxindole natural products perophoramidine and the communesin. LÄS MER