Sökning: "CD39"

Visar resultat 1 - 5 av 13 avhandlingar innehållade ordet CD39.

1. 1. Regulatory T cells and mucosal-associated invariant T cells in colon adenocarcinomas; Phenotype and function

   Författare :Filip Ahlmanner; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colon cancer; regulatory T cells; CD39; adenosine; immune checkpoint molecules; immunosuppression; MAIT cells; cytokines; cancer-specific survival;

   Sammanfattning : In many solid cancers, and also in colon adenocarcinomas, an increased accumulation of lymphocytes is beneficial for the patient. However, tumor-infiltrating immune cells may be either pro- or anti-tumorigenic and the balance between these two counteracting forces partly determines patient outcome. LÄS MER

3. 2. Immune Cell Profiling of Colorectal Cancers: Unravelling the Connection to Treatment Responses

   Författare :Azar Rezapour; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rectal cancer; Tumor infiltrating T cell; MxA; Interferon type I; CD39; CD103; PD-1; cytokines; response to the treatment;

   Sammanfattning : Understanding the interplay between tumor cells and the immune system holds the key to the development of more effective treatments for cancer patients. Therefore, we have emphasized our efforts on deciphering the intricacies of these interactions to pave for more effective therapeutic strategies. LÄS MER

4. 3. Att bära världen på sina axlar : Miljövetares uppfattningar av och förhållningssätt till miljöproblem och sin profession

   Författare :Magnus Johansson; Pedagogik; []
   Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; environmental education; professional competence; phenomenology; higher education; phenomenographic research; education for sustainable development; environmental education;

   Sammanfattning : The aim of the thesis is to investigate experiences of and ways of relating to environmental issues and towards their profession among a group of graduates in environmentla science. The respondents were either in the end of or had completed an educational program in Environmental sciences with a social science perspective offered at Malmö University. LÄS MER

5. 4. Structure and Phase Behavior of Protein Solutions

   Författare :Björn Persson; Beräkningskemi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Statistical Mechanics; Simulations; Protein Interactions; Phase Separation; Aggregation; Mutual Amplification;

   Sammanfattning : The complexity of proteins is reflected in the structure of their fluids. This is seen from strongly inhomogeneous distributions about the single protein. Using molecular simulations of protein models, based on experimental structures, the present work probes the directional forces between proteins. LÄS MER

7. 5. ADP regulation of insulin secretion and beta-cell apoptosis

   Författare :Chanyuan Tan; Kardiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; P2Y; β-cell; ADP; insulin; apoptosis; autocrine; ectonucleotidase;

   Sammanfattning : The aims of this dissertation were to investigate the effects of extracellular purines on insulin secretion, and apoptosis in mouse pancreatic islets and β-cells; to examine if high glucose and free fatty acids induces β-cell apoptosis via autocrine effects of ADP acting on the P2Y13 receptor; and to investigate the modulation of extracellular purines in vascular smooth muscle cells (VSMCs) through ectonucleotidase or ATP release under the effect of high glucose. The expression of the ADP receptors P2Y1 and P2Y13 were shown in both mouse pancreatic islets and isolated β-cells using real-time PCR quantification. LÄS MER