Sökning: "Lene Uhrbom"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden Lene Uhrbom.

1. 1. Roles of p16INk a and PDGF-B in glioma

   Författare :Lene Uhrbom; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; autocrine; glioma; INK4a; PDGF; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

   Sammanfattning : Gliomas are diffuse astrocytic tumors of the central nervous system (CNS) which usually affect adults. This thesis work has focused on molecular mechanisms of altered growth control in glioma, and the significance of two gene products belonging to pathways commonly affected in glioma, p16INK4a and PDGF-B, has been investigated in vitro and in vivo. LÄS MER

3. 2. Investigations of Proneural Glioblastoma to Identify Novel Therapeutic Targets

   Författare :Maria Boije; Lene Uhrbom; Bengt Westermark; Rolf Bjerkvig; Uppsala universitet; []
   Nyckelord :Glioma; proneural subtype; hallmarks; glioma initiating cells; S-SOX5; angiogenesis; stromal cells; Tumour biology; Tumörbiologi; Experimentell patologi; Experimental Pathology;

   Sammanfattning : Malignant glioma is a highly lethal and destructive disease with no proper cure. We have investigated some of the hallmarks of cancer in connection to glioma and found ways to disrupt these and prevent tumor growth. The work is done within the context of a glioma subtype distinguished by activation of PDGF signaling termed the proneural subtype. LÄS MER

4. 3. From Genes to Therapy : Modeling and Novel Therapeutic Strategies for Brain Tumors

   Författare :Matko Čančer; Fredrik Swartling; Lene Uhrbom; Suzanne J. Baker; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medulloblastoma; Glioblastoma; MYCN; PDGF; Cancer Therapy; BET bromodomains; Temozolomide; Medicinsk vetenskap; Medical Science; Oncology; Onkologi;

   Sammanfattning : Medulloblastoma is the most common malignant pediatric brain tumor and is molecularly divided into four subgroups – WNT, SHH, Group 3 and Group 4. Two thirds of medulloblastoma patients survive, but survivors often suffer from severe, lifelong side-effects. The MYCN oncogene is deregulated in many medulloblastoma patients. LÄS MER

5. 4. Glioblastoma heterogeneity and plasticity : Investigating the roles of BMP4 and SOX2

   Författare :Erika Dalmo; Bengt Westermark; Fredrik J. Swartling; Lene Uhrbom; Ana Martin-Villalba; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioblastoma; SOX2; BMP4; senescence; plasticity; Oncology; Onkologi; Medicinsk vetenskap; Medical Science; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

   Sammanfattning : The malignant primary brain tumor glioblastoma has a dismal prognosis and is distinguished by its heterogeneous character. Current treatment with surgical resection, radiotherapy and adjuvant chemotherapy with the alkylating agent temozolomide does not provide a cure, but simply prolongs survival by a few months. LÄS MER

7. 5. Interplay Between Cell of Origin and Oncogenic Activation in Glioma

   Författare :Yiwen Jiang; Lene Uhrbom; Anders Persson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioma; PDGF; cell of origin; Sox5; glioma initiating cells; Oncology; Onkologi;

   Sammanfattning : Glioma is the most frequent primary tumor of the central nervous system. By using the RCAS/tv-a mouse glioma model, we have studied mechanisms controlling glioma development and the effect of cell of origin on these processes.SOX5 was identified as a brain tumor locus in a retroviral insertional mutagenesis screen of PDGF-B induced mouse gliomas. LÄS MER