Avancerad sökning

Hittade 2 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Symmetry of Halonium Complexes in Solution

    Författare :Anna-Carin Carlsson; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; bis pyridine -based halonium complexes; ethylenehalonium ions; structure symmetry; isotopic perturbation of equilibrium; solution NMR spectroscopy; isotope effects; N-X -N halogen bond; C-X -C interaction;

    Sammanfattning : In this thesis the symmetry of two interaction types involving electropositive halogens have been studied in solution; the N-X+-N halogen bond (X = Br or I), and the C-X+-C interaction of previously characterised, cyclic, 1,2-bridged halonium ions (X = Cl or Br), respectively. The three N-X+-N model structures included are bispyridine, 1,2-bis(pyridine-2-ylethynyl)benzene and 1,2-bis((4-methylpyridin-2-yl)ethynyl)benzene halonium triflate complexes. LÄS MER

  3. 2. Synthesis of Novel Homoserine Analogues - Towards t he Development of Substrate-based Peptide Inhibitors of cAMP-dependent Protein Kinase

    Författare :Anna-Carin Carlsson; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein kinases; protein kinase inhibitors; substrate-based kinase inhibitors; cAMP-dependent protein kinase; kemptide; homoserine; asymmetric -amino acid synthesis; glycine -anion equivalents; Schöllkopf’s bislactim ether; epoxidation; nucleophilic epoxide ring opening; microwave-assisted synthesis;

    Sammanfattning : Protein kinases are enzymes that via phosphorylation of proteins/peptides regulate most aspects of cell functions and physiology. The enzymes transfer a -phosphoryl group from ATP to hydroxyl groups of Ser, Thr and Tyr residues in their substrates. LÄS MER