Sökning: "[11C]methyl iodide"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden [11C]methyl iodide.

  1. 1. Methods for the Synthesis of PET Tracers and NMR Studies of Ribonuclease A

    Författare :Linda Samuelsson; Bengt Långström; Sharon Stone-Elander; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; [11C]methyl iodide; Stille reaction; palladium; Ribonuclease A; osmolytes; PFG-NMR; Organisk kemi; Organic chemistry; Organisk kemi;

    Sammanfattning : This thesis contains two parts.In the first part, general and versatile palladium-mediated 11C-C bond forming reactions for use in the production of radiotracers for Positron Emission Tomography (PET) were explored. LÄS MER

  3. 2. Palladium-promoted synthesis of compounds labelled with ¹¹C : Synthesis of ¹¹C-labelled prostacyclin and prostaglandin analogues

    Författare :Margareta Björkman; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemistry; Kemi; Chemistry; Kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : Palladium-promoted reactions have been employed for the synthesis of compounds labelled with 11C (t½ = 20.3 min). The precursor [11C]methyl iodide was used in palladium-promoted cross-coupling reactions with organostannanes. LÄS MER

  4. 3. Synthesis of 11C-labelled Alkyl Iodides : Using Non-thermal Plasma and Palladium-mediated Carbonylation Methods

    Författare :Jonas Eriksson; Bengt Långström; Philip H. Elsinga; Uppsala universitet; []
    Nyckelord :Organic chemistry; isotopic labelling; carbon-11; alkyl iodides; acrylamides; specific radioactivity; carbonylation; carbon monoxide; non-thermal plasma; PET; Organisk kemi;

    Sammanfattning : Compounds labelled with 11C (β+, t1/2 = 20.4 min) are used in positron emission tomography (PET), which is a quantitative non-invasive molecular imaging technique. It utilizes computerized reconstruction methods to produce time-resolved images of the radioactivity distribution in living subjects. LÄS MER

  5. 4. Catecholaminergic neurotransmission in heart and brain : development of tracers for positron emission tomography

    Författare :Claus Oliver Langer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :PET; Radioligand; Catecholamine; Norepinephrine; Dopamine; Heart; Brain; Metaraminol; Dopamine D2 Receptor;

    Sammanfattning : The catecholamines norepinephrine and its biosynthetic precursor dopamine are two principal neurotransmitters in the human central nervous system (CNS). Moreover, norepinephrine is a major transmitter substance in the peripheral, autonomic nervous system. LÄS MER

  7. 5. Development of radioligands for emission tomography imaging of dopamine D1 and benzodiazepine receptors

    Författare :Christian Foged; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Dopamine D1 receptors; Benzodiazepine BZ receptors; PET; SPECT.Stoc;

    Sammanfattning : Brain imaging of dopamine and benzodiazepine (BZ) receptors in vivo is of central interest in neuropsychiatric disorders such as schizoprenia, Huntington's disease and epilepsy. The objective was to develop new radioligands for emission tomography of dopamine D1 and BZ receptors. LÄS MER