Sökning: "Tumor suppressor gene TSG"

Visar resultat 6 - 10 av 12 avhandlingar innehållade orden Tumor suppressor gene TSG.

  1. 6. From a candidate region to gene characterization : analysis of three new genes with respect to meningioma tumorigenesis

    Författare :Myriam Peyrard; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :meningioma; central nervous system; monosomy 22; tumor suppressor gene; ADTBI BAM22 gene; clathrin-coated vesicles; adaptin; assembly protein;

    Sammanfattning : Meningioma is a common and usually benign tumor arising from the meninges covering the central nervous system (CNS). The yearly incidence of symptomatic meningiomas is 1.2 cases per 100 000 individuals but autopsy findings reveal an occurrence ten times higher. LÄS MER

  3. 7. DNA methylation and gene expression patterns in adrenal medullary tumors

    Författare :Nimrod G B Kiss; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Pheochromocytomas and abdominal paragangliomas are neuroendocrine tumors of the autonomous nervous system, arising in adrenal medulla and sympathetic ganglia throughout the abdomen. These tumors originate from catecholamine-producing chromaffin cells. Neuroblastomas are common childhood tumors in the adrenal medulla and abdominal ganglia. LÄS MER

  4. 8. A microcell hybrid based elimination test to identify human chromosome 3 regions that antagonize tumor growth

    Författare :Irina Kholodnyuk Holodnuka; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Deletions at multiple sites on the short arm of chr3 have been detected in many different types of human tumors. Each of the deleted regions is expected to harbor a tumor antagonizing/suppressor gene(s) (TSG). The earlier studies showed that the tumorigenicity of malignant cells could be suppressed by introducing a single human chr3. LÄS MER

  5. 9. Epigenetics in nasopharyngeal carcinoma

    Författare :Di Sun; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NPC; Methylation; TSG; EBV; LMP1; CDH13; RASSF2A; MMSP;

    Sammanfattning : Nasopharyngeal carcinoma (NPC) shows a remarkably distinctive ethnic and geographic distribution among the world suggesting that genetic susceptibility backgrounds cooperate with the environmental risk factors in etiology of NPCs. Among the environmental factors, much attention has been focused on a well-documented association with Epstein-Barr virus (EBV), which can be detected in 100% undifferentiated NPCs. LÄS MER

  7. 10. Genetic characterization of adrenocortical tumors

    Författare :Magnus Kjellman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Adrenocortical tumors; Comparative genomic hybridization; mutation analyzes; in situ hybridization; loss of heterozygosity; MEN 1;

    Sammanfattning : Adrenocortical cancer is a rare tumor form. However, adrenal tumors are today often found incidentally when using imaging techniques on the upper abdomen and should then be investigated. With the advance in molecular understanding of cancer new approaches to manage the disease may become available. LÄS MER