Sökning: "Klas Linderholm"

Hittade 1 avhandling innehållade orden Klas Linderholm.

  1. 1. Kynurenic acid in psychiatric disorders : studies on the mechanisms of action

    Författare :Klas Linderholm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Kynurenic acid, a metabolite of tryptophan along the kynurenine pathway, is an endogenous antagonist at NMDA- and α7* nicotinic acetylcholine- (α7*nACh) receptors. Previous studies have shown that elevated levels of endogenous kynurenic acid are associated with an increased firing of midbrain dopamine neurons as well as a reduced prepulse inhibition (PPI), a behavioral model for sensorimotor gating. LÄS MER