Sökning: "GSH transferase"

Visar resultat 16 - 20 av 20 avhandlingar innehållade orden GSH transferase.

  1. 16. Carcinogenic polycyclic aromatic hydrocarbons : theoretical, molecular, in vitro and cellular characterization of biotransformation and DNA damage

    Författare :Kristian Dreij; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Polycyclic aromatic hydrocarbons (PAHs) are widespread mutagenic and carcinogenic environmental pollutants, which require metabolic activation to electrophilic intermediates and subsequent covalent binding to critical targets in DNA to elicit their biological activity. Bayand fjord-region diol epoxides (DEs) have been identified as the ultimate mutagenic and carcinogenic metabolites of PAHs. LÄS MER

  3. 17. Characterization of human glutathione-dependent microsomal prostaglandin E synthase-1

    Författare :Staffan Thorén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Prostaglandins (PGs) are lipid mediators, which act as local hormones. PGs are formed in most calls and are synthesized de novo from membrane-released arachidonic acid (AA) upon cell activation. LÄS MER

  4. 18. mPGES-1 : a key regulator of fever and neonatal respiratory depression

    Författare :Sipra Saha; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Prostaglandins are potent lipid mediators, synthesized de novo from arachidonic acid (AA) upon cell activation. AA is oxidized by the cyclooxygenase isoenzymes (COX-1 and COX-2) to form PGH2, the common substrate for downstream enzymes involved in prostaglandin biosynthesis. LÄS MER

  5. 19. Studies of leukotriene C4 synthase isoenzymes and the cysteinyl leukotrine receptors in human endothelial- and mast cells

    Författare :Mattias Sjöström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Leukotriene (LT) C4, the parent compound of LTD4 and LTE4, is generated when LTA4 is conjugated with GSH by either leukotriene C4 synthase (LTC4S) or microsomal GSH S-transferase (MGST) type 2 or 3. Together these lipid mediators cause contractions particularly in airway smooth muscle and the microcirculation, leading to bronchconstriction, plasma extravasation and edema formation as well as increased mucus secretion from epithelial cells and recruitment of inflammatory cells. LÄS MER

  7. 20. Studies on molecular properties and functional regulation of terminal leukotriene C4 synthases and cysteinyl-leukotriene receptor signalling in human endothelium

    Författare :Oliver Schröder; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The transformation of the unstable intermediate leukotriene (LT) A4 into the glutathione conjugate LTC4, the parent compound of LTD4 and LTE4, is catalysed by leukotriene C4 synthase (LTC4S) as well as microsomal glutathione S-transferase type 2 (MGST2) and type 3 (MGST3). Together, these eicosanoids also known as cysteinyl leukotrienes (cys-LT) are key mediators of immediate hypersensitivity reactions. LÄS MER