Sökning: "Kristian Dreij"

Hittade 1 avhandling innehållade orden Kristian Dreij.

1. 1. Carcinogenic polycyclic aromatic hydrocarbons : theoretical, molecular, in vitro and cellular characterization of biotransformation and DNA damage

   Författare :Kristian Dreij; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Polycyclic aromatic hydrocarbons (PAHs) are widespread mutagenic and carcinogenic environmental pollutants, which require metabolic activation to electrophilic intermediates and subsequent covalent binding to critical targets in DNA to elicit their biological activity. Bayand fjord-region diol epoxides (DEs) have been identified as the ultimate mutagenic and carcinogenic metabolites of PAHs. LÄS MER