Avancerad sökning

Hittade 5 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Retinoids in experimental neuroblastoma therapy

    Författare :Frida Ponthan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Vitamin A; retinoids; neuroblastoma; 9-cis RA; Ro 13-6307; differentiation; apoptosis; growth inhibition; 13-cis RA; fenretinide; proton magnetic resonance spectroscopy; pharmacokinetic.;

    Sammanfattning : Retinoids are analogues of vitamin A, with documented activity against various malignant cell types. Neuroblastoma is a childhood tumour of the sympathetic nervous system that shows a complex clinical and biological heterogeneity, often with poor outcome despite intensive multimodal therapy. LÄS MER

  3. 2. Molecular aspects of retinol uptake and activation

    Författare :Martin Lidén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Retinoids (vitamin A derivatives) are essential for a wide variety of physiological processes, including embryonic development, growth, vision, reproduction, and maintenance of various epithelia and the immune system. 11-Cis-retinal serves as the chromophore of the visual pigments in the retina, whereas the hormonal retinoids, all-trans and 9-cis retinoic acid (RA), regulate the non-visual functions via activation of nuclear retinoid receptors (RARs and RXRs). LÄS MER

  4. 3. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) disrupts vitamin A homeostasis in rodents : quantitative and mechanistic studies to support risk assessment

    Författare :Nick Fletcher; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) exposure is well-known to disrupt Vitamin A (retinoid) homeostasis in rats, resulting in decreased hepatic storage, as well as increased metabolism and excretion of retinoids. The aims of this thesis were (1) to clarify the species and strain sensitivity of TCDDinduced retinoid disruption and (2) to identify cellular targets of TCDD-induced retinoid disruption. LÄS MER

  5. 4. Toxicity of brominated flame retardants with focus on retinoid system disturbances

    Författare :Sabina Litens Karlsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Brominated flame retardants (BFR) are detected in the environment and biota all over the world. They contribute to the human body burden of industrial chemicals and exposure is mainly via food. Indoor dust contributes substantially in some exposure situations, which involve small children. LÄS MER

  7. 5. In vitro studies of retinoids and arsenic in non-M3 acute myeloid leukemia

    Författare :Sören Lehmann; Karolinska Institutet; Karolinska Institutet; Sweden Stockholm Huddinge University Hospital Department of Medicine; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Despite advances in the treatment of patients with acute myeloid leukemia (AML), the majority of the patients will die from their disease. The current intensive therapy for AML is also complicated my substantial morbidity and mortality and, as a result, many patients cannot be given the most effective therapy. LÄS MER