Sökning: "systemic vasculitis"

Visar resultat 1 - 5 av 22 avhandlingar innehållade orden systemic vasculitis.

1. 1. Studies on the Epidemiology and Outcome of Primary Systemic Vasculitis

   Författare :Aladdin Mohammad; Njurmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; polyarteritis nodosa; survival; microscopic polyangiitis; arteritis; vasculitis damage index; Vasculitis; ANCA; Wegener s granulomatosis; Churg-Strauss syndrome;

   Sammanfattning : Primary Systemic Vasculitides [PSV: Wegener's granulomatosis (WG), microscopic polyangiitis (MPA), Churg-Strauss syndrome (CSS) and polyarteritis nodosa (PAN)] are rare systemic diseases of unknown etiology; if untreated, they are associated with high morbidity and mortality rates. Changes in the classification and diagnostic improvements during the last decades have increased reported prevalence and incidence rates of PSV. LÄS MER

3. 2. Kinin System Activation in Vasculitis

   Författare :Robin Kahn; Lund Pediatrik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; kinin receptors; inflammation; vasculitis; proteinase 3; neutophils; anti-neutrophil-cytoplasmic antibodies; Kinin;

   Sammanfattning : The kinin system is activated when high-molecular-weight kininogen (HK) is cleaved by plasma kallikrein thus generating bradykinin. Bradykinin is a potent proinflammatory peptide that induces plasma leakage, blood pressure drop, liberation of inflammatory cytokines and pain. LÄS MER

4. 3. Diagnostic and prognostic aspects of anti-neutrophil cytoplasmic antibodies in systemic vasculitis

   Författare :Daina Selga; Njurmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Immunologi; serologi; serology; epitope; Wegener s granulomatosis; microscopic polyangiitis; polyarteritis nodosa; capture ELISA; Immunology; anti-neutrophil cytoplasmic antibody; proteinase 3; vasculitis; nephrology; Urologi; nefrologi; Urology;

   Sammanfattning : Primary systemic vasculitis is associated with a high mortality if left untreated and it is essential to make the diagnosis before permanent organ damage has occurred. In this thesis the diagnostic and prognostic significance of anti-neutrophil cytoplasmic antibodies (ANCA) in systemic vasculitis is investigated. LÄS MER

5. 4. Autoantibody profiling in autoimmune diseases

   Författare :Shaghayegh Bayati; Peter Nilsson; Elisa Pin; Peter Heeringa; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Autoimmunity; Autoantibodies; Vasculitis; Systemic Sclerosis; affinity proteomics; Biotechnology; Bioteknologi;

   Sammanfattning : Autoimmune disease diagnosis and definition of prognosis can be challenging. Patients with the same autoimmune disease could present with very heterogeneous symptoms. Therefore, there is a need to understand the disease better to improve patients’ diagnosis, and classification, and tailor the treatment. LÄS MER

7. 5. The Balance between Pro- and Antiinflammatory Molecules in ANCA-Associated Vasculitis

   Författare :Sophie Ohlsson; Njurmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nephrology; Urologi; nefrologi; Urology; monocyte; SLPI; proteinase 3; ANCA; vasculitis; inflammation;

   Sammanfattning : ANCA-associated systemic vasculitis (AASV) is a group of inflammatory disorders, characterized by inflammation and necrosis of blood vessels and frequently granuloma formation. Patients with AASV make autoantibodies, so called ANCA, against proteins present in the granules of neutrophils and monocytes, mainly proteinase 3 (PR3) and myeloperoxidase (MPO). LÄS MER