Sökning: "short stature."

Visar resultat 11 - 15 av 34 avhandlingar innehållade orden short stature..

  1. 11. GH Secretion in children. Methodological aspects of determining immunoreactive and bioactive isoforms

    Författare :Chatarina Löfqvist; Göteborgs universitet; []
    Nyckelord :Growth hormone; immunoassay; cross-reactivity; standard; antibody; insulin-like growth factor 1; reference values;

    Sammanfattning : A child's hormone-dependent growth is dependent on multiple factors, although linear growth is closely associated with levels of growth hormone (GH) secretion. As GH in serum exists in several isoforms, some of which may not be identified by immunoassay, possible alterations in the secretion of these different isoforms in childhood may influence growth and/or metabolism. LÄS MER

  3. 12. Placental Function : An Epidemiological and Magnetic Resonance Study

    Författare :Sara Sohlberg; Anna-Karin Wikstrom; Matts Olovsson; Ajlana Mulic-Lutvica; Johan Wikström; Karel Marsal; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; body height; body mass index; early preeclampsia; late preeclampsia; magnetic resonance imaging; placenta; perfusion; IVIM; risk factors; energy metabolism; magnetic resonance spectroscopy; 31P-MRS; Obstetrik och gynekologi; Obstetrics and Gynaecology;

    Sammanfattning : Placental function is central for normal pregnancy and in many of the major pregnancy disorders. We used magnetic resonance imaging techniques to investigate placental function in normal pregnancy, in early and late preeclampsia and in intrauterine growth restriction. LÄS MER

  4. 13. Regulation of insulin-like growth factor binding protein-1 (IGFBP-1) and implications in catabolic conditions

    Författare :Björn Lindgren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This thesis has studied the regulation of IGFBP-1 (insulin-like growth factor binding protein 1), which is one factor regulating the bioavailability of IGF-I with special interest how IGFBP-1 is regulated in vitro and in humans, especially in diabetes and catabolic conditions. The IGFBP-1 cDNA was cloned and used for studies in human hepatoma cells, HepG2, which showed that both insulin and IGF-I could decrease IGFBP-1 in the cell conditioned medium. LÄS MER

  5. 14. Metabolic effects and long-term safety of childhood growth hormone treatment

    Författare :Anders Tidblad; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The overall aim of this thesis was to investigate the metabolic effects and long-term safety of childhood growth hormone (GH) treatment. In order to achieve this aim, the different projects consist of a two-part clinical trial on metabolic features linked to GH physiology and GH treatment as well as two large population-based cohort studies with focus on the long-term cardiovascular and cancer risks in previously GH-treated patients. LÄS MER

  7. 15. Prader-Willi syndrome : diagnosis and effects of growth hormone treatment

    Författare :Ann Christin Lindgren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :DNA methylation test; genomic imprinting; glucose intolerance; growth hormone; Prader Willi syndrome; respiratory function;

    Sammanfattning : Prader-Willi syndrome (PWS) is a rare neurogenetic disorder characterised by hypotonia (especially pronounced in the perinatal period) with "failure to thrive", hypogonadism, hypoventilation, dysmorphic features, final short stature and mental retardation. From the age of 2 years hyperphagia develops leading to obesity if the caloric intake is not limited. LÄS MER