Sökning: "sample size"

Visar resultat 11 - 15 av 630 avhandlingar innehållade orden sample size.

  1. 11. Finding fitness : empirical and theoretical explorations of inferring fitness effects from population-level SNP data

    Författare :Bea Angelica Andersson; Xiao-Ru Wang; Åke Brännström; Tanja Slotte; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; distribution of fitness effects; site frequency spectra; missing data filtering; downsampling; imputation; sample size; population structure; inbreeding; selfing; homozygosity; Arabidopsis; Pinus; DFE-alpha; SLiM; population genomics; adaptation; biology; biologi; evolutionär genetik; evolutionary genetics; populationsbiologi; Population Biology; molekylärbiologi; Molecular Biology; Genetics; genetik;

    Sammanfattning : The distribution of fitness effects (DFE) describes the likelihood that a new mutation has a specific effect on the fitness of an individual in a given population. The shape of the DFE is a result of several factors such as population size, mating system and selective environment, and can in turn influence the evolutionary potential of a species. LÄS MER

  3. 12. Model-Based Optimization of Clinical Trial Designs

    Författare :Camille Vong; Mats O. Karlsson; Andrew C. Hooker; Lena E. Friberg; Marylore Chenel; Oliver Sander; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonlinear mixed-effects models; pharmacometrics; likelihood ratio test; NONMEM; power; sample size; study design; proof-of-concept; dose-finding; population optimal design; LOQ; BQL data; neutropenia; docetaxel; myelosuppression; thrombocytopenia; MTD; Bayesian methods; 3 3 algorithm; dose escalation study; Pharmaceutical Science; Farmaceutisk vetenskap;

    Sammanfattning : General attrition rates in drug development pipeline have been recognized as a necessity to shift gears towards new methodologies that allow earlier and correct decisions, and the optimal use of all information accrued throughout the process. The quantitative science of pharmacometrics using pharmacokinetic-pharmacodynamic models was identified as one of the strategies core to this renaissance. LÄS MER

  4. 13. Longitudinal Models for Quantifying Disease and Therapeutic Response in Multiple Sclerosis

    Författare :Ana M. Novakovic; Mats O. Karlsson; Etienne Pigeolet; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonlinear mixed-effects models; pharmacometrics; NONMEM; multiple sclerosis; cladribine; EDSS; item response theory; relapse rate; absolute lymphocyte count; total volume T2 lesions; burden of disease; power; sample size; Pharmaceutical Science; Farmaceutisk vetenskap;

    Sammanfattning : Treatment of patients with multiple sclerosis (MS) and development of new therapies have been challenging due to the disease complexity and slow progression, and the limited sensitivity of available clinical outcomes. Modeling and simulation has become an increasingly important component in drug development and in post-marketing optimization of use of medication. LÄS MER

  5. 14. Comparative morphological studies of fossil and living plane trees (Platanaceae) and oaks (Quercus): taxonomy, ecology, evolution

    Författare :Georg Florian Tschan; Thomas Denk; Ove Eriksson; Bertil Ståhl; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Platanaceae; Platanus; Credneria; Quercus; Galliferae; leaf architecture; epidermal anatomy; comparative morphology; character variation; variability; sample size; diversity patterns; species concepts; ecology; biogeography; evolution; plant fossils; Plant Ecology; växtekologi;

    Sammanfattning : Morphological characters are essential for flowering plant identification, but also provide information about diversity patterns and ecological adaptation. In woody plant species, characters of the leaf are among the most useful and can be examined on fossils as well. LÄS MER

  7. 15. Fundamental Studies on Direct Injection Nebulisers for Sample Introduction in ICP Spectrometry : Aerosol Properties, ICP Characteristics and Analytical Performance

    Författare :Daniel Goitom Asfaha; Wolfgang Frech; Ralph Edward Sturgeon; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ICP; ICP-MS; ICP-OES; sample introduction; DIHEN; Vulkan DIN; non-spectral interferences; noise power spectra; analytical precision; plasma diagnostic parameters; particle dynamic analysis PDA ; Analytical chemistry; Analytisk kemi;

    Sammanfattning : The performance of different types of nebulisers: Vulkan direct injection nebuliser (Vulkan DIN), direct injection high efficiency nebuliser (DIHEN), microconcentric nebuliser coupled to cyclonic or double pass spray chamber (MCN-C or MCN-DP, respectively) was investigated and compared when used for sample introduction to ICP-MS or ICP-OES. With ICP-OES, in axial viewing mode, intensity distributions across the radius of the plasma (radial intensity profiles) were determined for different spectral lines with Esum 1. LÄS MER