Sökning: "absolute lymphocyte count"

Hittade 3 avhandlingar innehållade orden absolute lymphocyte count.

  1. 1. Longitudinal Models for Quantifying Disease and Therapeutic Response in Multiple Sclerosis

    Författare :Ana M. Novakovic; Mats O. Karlsson; Etienne Pigeolet; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonlinear mixed-effects models; pharmacometrics; NONMEM; multiple sclerosis; cladribine; EDSS; item response theory; relapse rate; absolute lymphocyte count; total volume T2 lesions; burden of disease; power; sample size; Pharmaceutical Science; Farmaceutisk vetenskap;

    Sammanfattning : Treatment of patients with multiple sclerosis (MS) and development of new therapies have been challenging due to the disease complexity and slow progression, and the limited sensitivity of available clinical outcomes. Modeling and simulation has become an increasingly important component in drug development and in post-marketing optimization of use of medication. LÄS MER

  3. 2. Rituximab-induced neutropenia : clinical and patophysiological studies

    Författare :Daniel Tesfa; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Rituximab is a monoclonal antibody directed against the CD20 antigen on normal and neoplastic B-lymphocytes. It was originally developed for treatment of lymphomas as a targeted therapy against CD20 positive non-Hodgkin lymphomas (NHL). More recently, its use has expanded into patients with rheumatic diseases. LÄS MER

  4. 3. Regulation of innate and acquired immunity in infants by commensal bacteria

    Författare :Helen Karlsson; Göteborgs universitet; []
    Nyckelord :intestinal microflora; commensal; antigen-presenting cells; dendritic cells; CD25 regulatory T cells; allergy; infants; Staphylococcus aureus;

    Sammanfattning : The incidence of atopic diseases in children is steadily increasing in the industrialised world along with an improved hygienic lifestyle. The gastrointestinal flora may be of specific importance for the proper maturation of the immune system and for the induction of tolerance, in which CD25+ regulatory T cells (Tregs) play a crucial role. LÄS MER