Sökning: "prostaglandin metabolism"

Visar resultat 1 - 5 av 31 avhandlingar innehållade orden prostaglandin metabolism.

  1. 1. Cell signalling in cancer. A functional and immunochemical investigation of purinergic,adrenergic, nitrergic, and prostaglandin mediated signalling mechanisms in experimental and human cancer

    Författare :Gunnar Nylund; Göteborgs universitet; []
    Nyckelord :adenosine-5´-triphosphate; colon cancer; extracellular acidification; melanoma; ; microphysiometer; nitric oxide; noradrenaline; prostaglandin E2; sarcoma; tumour cell; metabolism; uridine-5´-triphosphate;

    Sammanfattning : Disturbed cell signalling is a hallmark of the cancer cell, being one important mechanismbehind uncontrolled cell growth. In the current study, we have investigated cancer cellsignalling with the focus on some first messenger and/or their receptors, in the murine celllines, MCG 101, and K1735-M2, and the human colon cancer cell line, HT-29. LÄS MER

  3. 2. Osteoprotegerin in Bone Metabolism

    Författare :Helena Brändström; Uppsala universitet; []
    Nyckelord :Medical sciences; Bone; osteoprotegerin; osteoblasts; polymorphism; cytokines; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Sammanfattning : Bone turnover, remodeling, is a constant process replacing old bone with new. This complex cellular event involves resorption by osteoclasts and formation of new bone by osteoblasts. The balance between osteoblastic and osteoclastic activity is under regulation by several endocrine and paracrine factors. LÄS MER

  4. 3. The Role of Cyclooxygenase-2 in Models of Epilepsy and Traumatic Brain Injury : Effects of Selective Cyclooxygenase-2 Inhibitors

    Författare :Tina Kunz; Tadeusz Wieloch; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Controlled cortical contusion injury; fluid percussion injury; limbic seizures; nuclear factor-kappa B; prostaglandin metabolism; TUNEL staining; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; farmaceutisk farmakologi; Pharmaceutical Pharmacology;

    Sammanfattning : Cyclooxygenase-2 (COX-2) catalyses prostaglandin synthesis from arachidonic acid during inflammation. COX-2 is expressed in the normal brain and is induced in neurological disorders. There is evidence that COX-2 is involved in secondary events leading to cell death in the brain. LÄS MER

  5. 4. Mass Spectrometric Analysis of Oxylipins : Application to Cytochrome P450-Dependent Metabolism

    Författare :Tomas Nilsson; Ernst Oliw; Johan Bylund; Mikael Hedeland; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epoxyalcohols; fatty acids; hydroperoxides; electrospray ionization; ichthyosis; CYP4; linear ion trap; fragmentation mechanism; Pharmaceutical pharmacology; Farmaceutisk farmakologi; Biochemical Pharmacology; Biokemisk farmakologi;

    Sammanfattning : Cytochrome P450 (CYP) family 4 constitutes monoxygenases responsible for hydroxylation of fatty acids and other lipids. For example, CYP4F3 metabolizes leukotrienes and CYP4F8 prostaglandin H. Importantly, six of the twelve CYP4 enzymes are orphans, i.e. LÄS MER

  7. 5. Effects of low-load repetitive work and mental load on sensitising substances and metabolism in the trapezius muscle

    Författare :Gerd Flodgren; Gisela Sjøgaard; Umeå universitet; []
    Nyckelord :work-related muscle pain; microdialysis; near-infrared spectroscopy; electromyography; glutamate; lactate; pyruvate; prostaglandin E2; norepinephrine; Occupational and Environmental Medicine; arbets- och miljömedicin;

    Sammanfattning : Low-load repetitive work (LLRW) and mental load are important risk factors for the development of workrelated muscle pain. The link between these risk factors and the development of pain is still not understood, but stimulation of chemo-sensitive receptors in the muscle probably plays an important role. LÄS MER