Sökning: "microphysiometer"

Hittade 2 avhandlingar innehållade ordet microphysiometer.

  1. 1. Cell signalling in cancer. A functional and immunochemical investigation of purinergic,adrenergic, nitrergic, and prostaglandin mediated signalling mechanisms in experimental and human cancer

    Författare :Gunnar Nylund; Göteborgs universitet; []
    Nyckelord :adenosine-5´-triphosphate; colon cancer; extracellular acidification; melanoma; ; microphysiometer; nitric oxide; noradrenaline; prostaglandin E2; sarcoma; tumour cell; metabolism; uridine-5´-triphosphate;

    Sammanfattning : Disturbed cell signalling is a hallmark of the cancer cell, being one important mechanismbehind uncontrolled cell growth. In the current study, we have investigated cancer cellsignalling with the focus on some first messenger and/or their receptors, in the murine celllines, MCG 101, and K1735-M2, and the human colon cancer cell line, HT-29. LÄS MER

  3. 2. Microphysiometry in the evaluation of cytotoxic drugs with special emphasis on the novel cyanoguanidine CHS 828

    Författare :Sara Ekelund; Sigurd Vitols; Uppsala universitet; []
    Nyckelord :Medical sciences; Cytotoxic drug development; Cytosensor microphysiometer; cellular metabolism; CHS 828; guanidino-containing compound; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

    Sammanfattning : This thesis describes the use of a new technology, the Cytosensor® microphysiometer, in the in vitro evaluation of cytotoxic drugs, using the lymphoma cell line U-937 GTB and primary cultures of tumour cells from patients as model systems. The method was specifically applied to study the metabolic effects of the novel cyanoguanidine N-(6-(4-chlorophenoxy)hexyl)-N’-cyano-N’’-4-pyridylguanidine, CHS 828, currently in phase I/II clinical trials. LÄS MER