Sökning: "prepubertal growth"

Visar resultat 6 - 10 av 18 avhandlingar innehållade orden prepubertal growth.

1. 6. Effects of growth factors on chondrocyte proliferation and differentiation

   Författare :Caroline Edwall-Arvidsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Growth plate cartilage; limb buds; growth factors; proliferation; differentiation; collagens; c-fos; ALP;

   Sammanfattning : Longitudinal bone growth is regulated at the level of growth plate chondrocytes by circulating or locally produced hormones and growth factors. Present investigation focused on the effects of growth hormone (GH) and growth factors on chondrocyte proliferation and differentiation during pre- and postnatal cartilage development. LÄS MER

3. 7. Auxological tools for following growth in extreme short stature and for evaluating growth promoting interventions

   Författare :Andrea Merker; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Growth charts are inevitable tools for following children in clinical practice and also when evaluating growth promoting therapy. Growth is a concern especially for families to children of extreme short stature such as in skeletal dysplasias but evaluations of growth pattern with changes in height position is complicated when height develops far below normal population range. LÄS MER

4. 8. Prader-Willi syndrome : diagnosis and effects of growth hormone treatment

   Författare :Ann Christin Lindgren; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :DNA methylation test; genomic imprinting; glucose intolerance; growth hormone; Prader Willi syndrome; respiratory function;

   Sammanfattning : Prader-Willi syndrome (PWS) is a rare neurogenetic disorder characterised by hypotonia (especially pronounced in the perinatal period) with "failure to thrive", hypogonadism, hypoventilation, dysmorphic features, final short stature and mental retardation. From the age of 2 years hyperphagia develops leading to obesity if the caloric intake is not limited. LÄS MER

5. 9. Insulin and growth hormone : regulation of adipocyte metabolism during infancy and childhood

   Författare :Ashraf Fawzy Kamel; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :human; rat; development; adipocytes; lipolysis; lipogenesis; glucose transport GLUT1; GLUT4; insulin; insulin receptor; growth hormone; growth hormone receptor microdialysis; obesity; Prader-Willi syndrome;

   Sammanfattning : The aim of the present investigation was to investigate the role of insulin and growth (GH) in adipose tissue metabolism during development. Lipolysis and lipogenesis were studied in isolated adipocytes from humans and rats of various ages. LÄS MER

7. 10. Metabolic effects and long-term safety of childhood growth hormone treatment

   Författare :Anders Tidblad; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The overall aim of this thesis was to investigate the metabolic effects and long-term safety of childhood growth hormone (GH) treatment. In order to achieve this aim, the different projects consist of a two-part clinical trial on metabolic features linked to GH physiology and GH treatment as well as two large population-based cohort studies with focus on the long-term cardiovascular and cancer risks in previously GH-treated patients. LÄS MER