Sökning: "papillary thyroid carcinoma"

Visar resultat 6 - 10 av 11 avhandlingar innehållade orden papillary thyroid carcinoma.

  1. 6. Diagnostic and prognostic markers in thyroid carcinoma with focus on TERT activation

    Författare :Ninni Mu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Well-differentiated follicular cell-derived thyroid carcinomas are usually categorized into papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC), which represent the most common and second most common types of thyroid carcinoma, respectively. PTC patients generally have a good prognosis, although a subset of patients progress in their disease with poor clinical outcome. LÄS MER

  3. 7. Basic and translational studies of follicular thyroid neoplasia

    Författare :Theodoros Foukakis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Follicular thyroid cancer; follicular thyroid adenoma; PAX8-PPARgamma; PPARgamma; PTEN; RAS; RASSF1A; NORE1A; TERT; quantitative RT-PCR; microarray; cancer biomarker;

    Sammanfattning : Thyroid tumors occur frequently in the general population and although the majority represents benign follicular adenomas (FTA), thyroid cancer constitutes 1% of all malignancies worldwide. Among the differentiated cancers, three main types are recognized, including the papillary and follicular forms (PTC and FTC) that originate from the follicular thyrocytes, and the medullary carcinoma that arises from the C-cells. LÄS MER

  4. 8. Behind the scenes of thyroid tumors : underlying genetic mechanisms

    Författare :Jia Jing Lee; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Familial medullary thyroid cancer; follicular thyroid cancer; anaplastic thyroid cancer; CCND1; UBCH10; p16; RASSF1A; BRAF; array-CGH; tumor progression; global methylation; LINE-1; LUMA;

    Sammanfattning : Thyroid cancer is the most frequently observed malignancy involving endocrine tissues. This group of diseases is also the major cause of death related to neoplasia of the endocrine system. Tumors in the thyroid gland are common in the general population and the majority represents benign follicular adenoma (FTA). LÄS MER

  5. 9. In search of diagnostic and prognostic markers for thyroid cancer : a proteomics approach

    Författare :Anastasios Sofiadis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Thyroid tumors; thyroid proteomics; S100A6; MIB-1; 2DE; MALDI-TOF-MS; SELDI-TOF-MS; protein pre-fractionation;

    Sammanfattning : Early diagnosis of cancer can influence the therapeutic strategy increasing the chances of cure or, at least, prolonged survival. It is equally important to be able to detect prognostic signs, i.e. tumor features that characterize its behavior. LÄS MER

  7. 10. Promoter mutations/methylation in thyroid and urothelial carcinomas : biological and clinical implications

    Författare :Xiangling Xing; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Genetic and epigenetic aberrations are well established to drive cancer development and progression. However, the underlying mechanisms are incompletely understood, and the translational applications of aberrant alterations are limited in gene non-coding regions, such as the promoter locus. LÄS MER