Sökning: "nucleus basalis"

Hittade 5 avhandlingar innehållade orden nucleus basalis.

  1. 1. Modeling disturbances of cholinergic systems : possible relevance for schizophrenia

    Författare :Anna Mattsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cholinergic; nucleus basalis; 192 IgG-saporin; schizophrenia; locomotor activity; dopamine; microdialysis; memory; MRI;

    Sammanfattning : Schizophrenia is a severe, chronic mental disorder. The etiology remains unknown but alterations in cholinergic neurotransmission is one, among other, disturbances in the brain that have been implicated in schizophrenia. LÄS MER

  3. 2. Somatostatin neurotransmission : studies on experimentally induced cognitive changes and Alzheimer’s disease

    Författare :Lars Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Alzheimer s disease Adenylyl cyclase Autoradiography Behavior Cerebral cortex DemenbaEnvironment Ibotenic acid lesion In-situ hybridization Learning Neuropeptides Northern blot Nucleus basalismagnocellularis Posttranslational processing Rat Recepto;

    Sammanfattning : Several neuropeptides are widely distributed in regions of the central nervous system (CNS) which are associated with cognitive functions. Multiple studies on postmortem Alzheimer's disease (AD) brains have shown depleted neuropeptide content and morphological abnormalities of somatostatin (SS)-containing interneurons in the hippocampus and the cerebral cortex. LÄS MER

  4. 3. Dementia with Lewy bodies - a clinical and neurological approach

    Författare :Elisabet Londos; Klinisk minnesforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimers diseases; Clinical features; Neuropathology; Cerebral Blood Flow; Gerontologi; Gerontology; Dementia; Lewy bodies;

    Sammanfattning : Dementia with Lewy bodies (DLB) is a dementia disorder, clinically characterized by fluctuating cognitive impairment, attention deficits, visual hallucinations, parkinsonism and other neuropsychiatric features. Sensitivity to neuroleptic medication is a common finding. LÄS MER

  5. 4. Modulation of acetylcholine release by serotonergic 5-HT1A and 5-HT1B receptors : a microdialysis study in the awake rat

    Författare :Xiao Jing Hu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Microdialysis; Acetylcholine; Serotonin; 5-HT1A receptor; 5-HT1B receptor; Frontal cortex; Ventral hippocampus;

    Sammanfattning : The aim of the thesis was to investigate the effects of the 5-HT1A receptor antagonist robalzotan (NAD-299) and the 5-HT1B receptor antagonist NAS-181 ((R)-(+)-2-(3-morpholinomethyl-2Hchromen-8-yl) oxymethyl-morpholine methanesulfonate) on cholinergic, glutamatergic and GABAergic neurotransmission in the rat brain in vivo. The extracellular levels of acetylcholine (ACh), glutamate (Glu) and GABA were monitored by microdialysis in the frontal cortex (FC) and ventral hippocampus (VHipp) in separate groups of awake rats. LÄS MER

  7. 5. On the role of forebrain cholinergic innervation for phencyclidine-induced behaviors and gene expression patterns

    Författare :Sophia Savage; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The basalo-cortical cholinergic innervation reaches neural targets in cortex cerebri where it modulates the incoming sensory information, regulating arousal, attention, vigilance, memory and cognition. Progressive de generation of the cholinergic neurons in the basal forebrain is considered a hallmark of Alzheimer ’s disease related to cognitive impairment in this condition. LÄS MER