Sökning: "nucleotide substitution"

Visar resultat 1 - 5 av 32 avhandlingar innehållade orden nucleotide substitution.

  1. 1. Nucleotide Substitution Patterns in Vertebrate Genomes

    Författare :Carina Farah Mugal; Hans Ellegren; Ziheng Yang; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; nucleotide substitutions; mutation rate variation; strand asymmetries; CpG effect; GC-biased gene conversion; codon evolution; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution;

    Sammanfattning : The rates and patterns at which nucleotide substitutions occur vary significantly across the genome sequence of vertebrates. A prominent example is the difference in the rate of evolution of functional sequences versus nonfunctional (neutrally evolving) sequences, which is explained by the influence of natural selection on functional sequences. LÄS MER

  3. 2. Characterization of non-coding mRNA in Epstein-Barr virus

    Författare :Åsa Isaksson; Göteborgs universitet; []
    Nyckelord :Epstein-Barr virus; EBNA1; IRES; PTLD; alternative splice; nucleotide substitution; protein interactions;

    Sammanfattning : Epstein-Barr virus (EBV) is a human gammaherpesvirus that infects lymphoid and epithelial cells. The virus is the causative agent of infectious mononucleosis, a self-limiting lymphoproliferative disease, and it is additionally associated with various malignancies including Burkitt?s lymphoma, Hodgkin?s disease and lymphoproliferative syndromes in immunocompromised individuals. LÄS MER

  4. 3. Comparative Genomics in Birds

    Författare :Erik Axelsson; Hans Ellegren; Martin Lercher; Uppsala universitet; []
    Nyckelord :Molecular genetics; Birds; molecular evolution; macrochromosomes; microchromosomes; mutation rate; substitution rate; base composition; positive selection; genetic drift; population size; Genetik;

    Sammanfattning : To shed light on forces that shape the molecular evolution of bird genomes, and in turn avian adaptations, comparative analyses of avian DNA sequences are important. Moreover, contrasting findings in birds to those of other organisms will lend a clearer view on general aspects of molecular evolution. LÄS MER

  5. 4. MHC and genomic diversity in Atlantic salmon (Salmo salar L.)

    Författare :Jakob Lohm; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Djurekologi; cytogenetik; Genetik; cytogenetics; Genetics; nucleotide diversity; isolation-by-distance; DGGE; AFLP; furunculosis; disease resistance; Arctic charr; brown trout; Atlantic salmon; population genetics; genetic variation; Mhc class IIB; Animal ecology;

    Sammanfattning : In this thesis I present studies concerning genomic diversity and genetic heterogeneity as well as the evolution and maintenance of genetic variation at a specific immune defence gene in Atlantic salmon (Salmo salar, L.). LÄS MER

  7. 5. Birds as a Model for Comparative Genomic Studies

    Författare :Axel Künstner; Hans Ellegren; Hanna Johannesson; Chris Ponting; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Birds; Selection; Gene expression; Sequence evolution; Next-generation sequencing; Comparative genomics; Molecular evolution; Genomics; Substitution Rates; Non-coding DNA; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution;

    Sammanfattning : Comparative genomics provides a tool to investigate large biological datasets, i.e. genomic datasets. In my thesis I focused on inferring patterns of selection in coding and non-coding regions of avian genomes. LÄS MER