Sökning: "alternative splice"

Visar resultat 1 - 5 av 75 avhandlingar innehållade orden alternative splice.

  1. 1. Regulation of alternative Pre-mRNA splicing : positive and negative control of adenovirus 3' splice site selection

    Författare :Oliver Mühlemann; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  3. 2. Understanding the Noise : Spliceosomal snRNA Profiling

    Författare :Lei Liu Conze; Anders Virtanen; Lars Wieslander; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ncRNA; snRNA; U1; splice site; alternative splicing; high-throughput sequencing; 454; SNP; Molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : The concept of the gene has been constantly challenged by new discoveries in the life sciences. Recent challenging observations include the high frequency of alternative splicing events and the common transcription of non-protein-coding-RNAs (ncRNAs) from the genome. The latter has long been considered noise in biological systems. LÄS MER

  4. 3. The balance of splicing : A novel insight into the splicing regulation of high-risk HPV E6 and E7 oncogenes

    Författare :Johanna Jönsson; Naoko Kajitani; Stefan Schwartz; Ola Forslund; Francesca Aguilo; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; HPV; splice donor; splice acceptor; cis-element; trans-acting factor; pre-mRNA splicing; splicing regulation.; Medical Virology; Medicinsk virologi;

    Sammanfattning : HPV is associated with several cancers. The genome consists of a long control region, early (E1, E2, E4, E5, E6 and E7) and late (L1 and L2) genes. The E6 and E7 proteins prevent cells from entering apoptosis and regulate the cell cycle. A deregulated expression of these can result in malignant transformations. LÄS MER

  5. 4. Alternative splicing of interleukin-7

    Författare :Nalini Kumar Vudattu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alternative splicing of pre-mRNA is the primary source of creating proteome diversity in humans; it is therefore highly relevant to disease and therapy. Alternative splicing has been described for many cytokines and these splice variants appear to function as either agonists or as antagonists of the wildtype cytokine. LÄS MER

  7. 5. CYP26B1 as regulator of retinoic acid in vascular cells and atherosclerotic lesions

    Författare :Ali Ateia Elmabsout; Allan Sirsjö; Karin Fransén; Helen Håkansson; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CYP26B1; alternative splice; vascular cells; atherosclerosis; alltrans-retinoic acid; gene polymorphism; inflammation; statins; Medicine; Medicin;

    Sammanfattning : Cardiovascular disease (CVD), currently the most common cause of morbidity and mortality worldwide, is caused mainly by atherosclerosis. Atherosclerosis is a chronic multifocal, immunoinflammatory, fibroproliferative disease of medium and large arteries. LÄS MER