Sökning: "multivariate analysis statistical experimental design"

Visar resultat 6 - 10 av 18 avhandlingar innehållade orden multivariate analysis statistical experimental design.

  1. 6. Optimal design for dose-finding studies

    Författare :Renata Eirini Tsirpitzi; Frank Miller; Kirsten Schorning; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bivariate model; distortion; drug combination; Elfving set; Emax model; Fedorov algorithm; mixed effects models; optimal experimental design; Statistics; statistik;

    Sammanfattning : One of the most complex tasks during the clinical development of a new drug is to find a correct dose. Optimal experimental design has as a goal to find the best ways to perform an experiment considering the available resources and the statistical model. Optimal designs have already been used to determine the design of dose-finding studies. LÄS MER

  3. 7. A strategy for ranking environmentally occuring chemicals

    Författare :Lennart Eriksson; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; QSAR; hazard ranking; statistical design; multivariate modelling; halogenated aliphatics; PCA; PLS;

    Sammanfattning : A systematic methodology for quantitative structure-activity relationship (QSAR) development in environmental toxicology is provided. The methodology is summarized in a strategy with six sequential steps. LÄS MER

  4. 8. Development of Protocols for Metabolomics in Biomedical Research using Chemometrics

    Författare :Anders Danielsson; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mass spectrometry; gas chromatography; design of experiments; Metabolomics; chemometrics; diabetes; metabolism; multivariate analysis;

    Sammanfattning : Metabolomics is a rapidly growing research field. It aims for quantification of all the metabolites in a biological sample such as plasma, saliva, cerebrospinal fluid or cells. LÄS MER

  5. 9. Practical application of machine learning for analyses of biological matrices and environmental phenomena

    Författare :Alexandra Walsh; Göteborgs universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Machine learning; Surface enhanced Raman spectroscopy; Acute lymphatic leukaemia; Volatile halogenated organic carbons; Marine algae; Doxorubicin; Principal component analysis; Multivariate statistics; Design of experiments; Waterlogged archaelogical wood; Transposed orthogonal partial least squares;

    Sammanfattning : This thesis presents research aimed at forwarding an understanding of machine learning methods as a method of studying complex matrices and environmental phenomena. A number of machine learning methods in the form of linear projection algorithms and statistical experimental designs were applied for qualitative analysis of different matrices. LÄS MER

  7. 10. Adapting Experimental and Monitoring Methods for Continuous Processes under Feedback Control : Challenges, Examples, and Tools

    Författare :Francesca Capaci; Erik Vanhatalo; Bjarne Bergquist; Murat Kulahci; Bart De Ketelaere; Luleå tekniska universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Continuous process; Statistical process control; Design of experiments; Engineering process control; Quality improvement; Simulation tools; Kvalitetsteknik och logistik; Quality technology and logistics; Kvalitetsteknik; Quality Technology Management;

    Sammanfattning : Continuous production covers a significant part of today’s industrial manufacturing. Consumer goods purchased on a frequent basis, such as food, drugs, and cosmetics, and capital goods such as iron, chemicals, oil, and ore come through continuous processes. LÄS MER