Sökning: "Doxorubicin"

Visar resultat 1 - 5 av 77 avhandlingar innehållade ordet Doxorubicin.

1. 1. Translational Tumor Drug Delivery : Doxorubicin formulation performance, intracellular uptake and molecular diffusion

   Författare :Oliver Degerstedt; Hans Lennernäs; Erik Sjögren; Per Hansson; Jessica Rosenholm; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; doxorubicin; drug diffusion; cellular uptake; drug delivery; PBPK modelling; hepatocellular carcinoma; emulsion; IC50; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : Globally, hepatocellular carcinoma (HCC) is the most common form of liver cancer and a leading cause of cancer death. One important risk factor is liver cirrhosis and the disease progression is characterized by deposition of extracellular matrix proteins that form a fibrous network, which increases liver stiffness and may limit the effectiveness of different treatment strategies. LÄS MER

3. 2. Biopharmaceutical investigations of doxorubicin formulations used in liver cancer treatment : Studies in healthy pigs and liver cancer patients, combined with pharmacokinetic and biopharmaceutical modelling

   Författare :Ilse R Dubbelboer; Hans Lennernäs; Erik Sjögren; Hartmut Derendorf; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; drug delivery system; in vivo release; PBPK modelling; hepatocellular carcinoma; doxorubicin; transarterial chemoembolization; drug disposition; Biofarmaci; Biopharmaceutics; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : There are currently two types of drug formulation in clinical use in the locoregional treatment of intermediate hepatocellular carcinoma (HCC). In the emulsion LIPDOX, the cytostatic agent doxorubicin (DOX) is dissolved in the aqueous phase, which is emulsified with the oily contrast agent Lipiodol® (LIP). LÄS MER

4. 3. p38 MAPK Signalling in Endothelial Apoptosis

   Författare :Simone Grethe; Malmö Experimentell patologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Naturvetenskap; Natural science; PP2A; Bad; Bcl-xL; doxorubicin; TNF; p38 MAPK; Apoptosis; endothelial cells;

   Sammanfattning : Endothelial apoptosis plays an important role in atherosclerosis, and a direct proapoptotic effect of chemotherapeutics on the tumour vasculature, emphasizes the great potency of antiangiogenic therapy in the treatment of cancer. We investigated signalling pathways in endothelial apoptosis induced by the inflammatory cytokine tumour necrosis factor alpha (TNF), the main target of which is the endothelium, and by the anticancer drug doxorubicin. LÄS MER

5. 4. Anthracyclines : Toxicity and chemotherapy-induced mucositis

   Författare :Fredrik Kullenberg; Hans Lennernäs; Erik Sjögren; David Dahlgren; Femke Heindryckx; Henrik Rönnberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anthracycline; doxorubicin; idarubicin; toxicity; intracellular concentration; IC50; chemotherapy-induced mucositis; apoptosis; proliferation; permeability; anti-inflammatory drugs; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : Anthracyclines belong to a class of cytostatic compounds that are commonly used to treat various types of cancers, including lymphoma, breast cancer and primary liver cancer. The aim of this thesis was to study how two anthracyclines, doxorubicin and idarubicin, induced cytotoxicity in tumor cells, as well as their off-target effect on the gastrointestinal system. LÄS MER

7. 5. Applications in Surface Enhanced Raman Spectroscopy

   Författare :Charlotte Eliasson; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; SERS; surface enhanced Raman spectroscopy; image analysis; lymphocytes; PCA; doxorubicin; living cells; PLS;

   Sammanfattning : The aim of this thesis is to address specific applications of Raman spectroscopy and specifically surface enhanced Raman spectroscopy, SERS. It includes an introduction to the techniques and several applications. The focus has been on how to achieve high precision SERS measurements, both qualitatively and quantitatively. LÄS MER