Sökning: "microwave-assisted chemistry"
Visar resultat 11 - 15 av 36 avhandlingar innehållade orden microwave-assisted chemistry.
11. Discovery of Small Peptides and Peptidomimetics Targeting the Substance P 1-7 Binding Site : Focus on Design, Synthesis, Structure-Activity Relationships and Drug-Like Properties
Sammanfattning : Biologically active peptides are important for many physiological functions in the human body and therefore serve as interesting starting points in drug discovery processes. In this work the neuropeptide substance P 1–7 (SP1–7, H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-OH), which has been demonstrated to reduce neuropathic pain and attenuate opioid withdrawal symptoms in animal models, has been addressed in a medicinal chemistry program with the overall aim of transforming this bioactive peptide into more drug-like compounds. LÄS MER
12. Palladium(II)-Catalyzed Coupling Reactions
Sammanfattning : Sustainable chemical processes are becoming increasingly important in all fields of synthetic chemistry. Catalysis can play an important role in developing environmentally benign chemical processes, and transition metals have an important role to play in the area of green chemistry. LÄS MER
13. Development of dynamic microwave and sonication-assisted extraction techniques coupled on-line to gas chromatography
Sammanfattning : This thesis describes the evaluation and construction of two solvent extraction methods for solid samples. The techniques are called Dynamic microwaveassisted extraction (I-III) and Dynamic sonication-assisted solvent extraction (IV-V). Both techniques are based on dynamic solvent extraction and are performed at elevated temperatures and pressures. LÄS MER
14. Antiadhesive agents targeting uropathogenic Escherichia coli : Multivariate studies of protein-protein and protein-carbohydrate interactions
Sammanfattning : This thesis describes studies directed towards development of novel antiadhesive agents, with particular emphasis on compounds that prevent attachment of bacteria to a host-cell. Three different proteins involved in the assembly or function of adhesive pili in uropathogenic Escherichia coli have been targeted either by rational structure based design or statistical molecular methods. LÄS MER
15. Synthesis of C(sp2)-P bonds by palladium-catalyzed reactions : Mechanistic investigations and synthetic studies
Sammanfattning : This thesis focuses on synthetic and mechanistic aspects of palladium-catalyzed C(sp2)-P bond-forming reactions, with the aim to develop mild and efficient methods for the synthesis of biologically active phosphorus compounds, e.g. DNA analogs. LÄS MER
