Sökning: "antiadhesive agents"

Hittade 3 avhandlingar innehållade orden antiadhesive agents.

  1. 1. Antiadhesive agents targeting uropathogenic Escherichia coli : Multivariate studies of protein-protein and protein-carbohydrate interactions

    Författare :Andreas Larsson; Jan Kihlberg; Fredrik Almqvist; Mats Larhed; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Antibacterial; pili; antiadhesive agents; structure based design; statistical molecular design; 2-pyridone; amino acid derivative; galabiose; enaminone; SPR; ELISA; QSAR; Organisk kemi; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : This thesis describes studies directed towards development of novel antiadhesive agents, with particular emphasis on compounds that prevent attachment of bacteria to a host-cell. Three different proteins involved in the assembly or function of adhesive pili in uropathogenic Escherichia coli have been targeted either by rational structure based design or statistical molecular methods. LÄS MER

  3. 2. Abdominal adhesions - clinical impact and experimental prevention

    Författare :Bobby Tingstedt; Lund Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; orthopaedics; anastomotic healing; adhesion prevention; polypeptides; long term follow-up; cost; non-specific abdominal pain; abdominal adhesions; small bowel obstruction; ortopedi; traumatologi; Kirurgi; traumatology; burst pressure;

    Sammanfattning : Intraabdominal adhesions are formed after most operations and a limited number of studies have to examine the long-term spectrum of adhesion-related disorders and the cost associated with this. Only a few numbers of antiadhesive agents are available which, however, do not decrease the actual morbidity that follows intraabdominal adhesions, such as small bowel obstruction, infertility and pain. LÄS MER

  4. 3. PREVENTION OF POSTSURGICAL ABDOMINAL ADHESIONS BY POLYPEPTIDES

    Författare :Laszlo Nehéz; Lund Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; traumatology; Surgery; orthopaedics; poly-L-glutamate; anastomotic healing; peritoneum; adhesion; prevention; poly-L-lysine; traumatologi; Kirurgi; ortopedi; polypeptides; surgery;

    Sammanfattning : Peritoneal adhesions develop after almost all abdominal surgical interventions and represent an important cause of postoperative intestinal obstruction, abdominal discomfort and infertility. Postoperative adhesions can potentially be reduced by using different antiadhesive agents. LÄS MER