Sökning: "medial prefrontal cortex"

Visar resultat 1 - 5 av 38 avhandlingar innehållade orden medial prefrontal cortex.

  1. 1. The prefrontal cortex and information processing : nitric oxide signaling studied in an animal model of schizophrenia

    Författare :Kim Fejgin; Göteborgs universitet; []
    Nyckelord :schizophrenia; nitric oxide; prepulse inhibition; phencyclidine; prefrontal cortex; cGMP; baclofen; cognition;

    Sammanfattning : The prefrontal cortex has been extensively linked to several cognitive domains that are severely compromised in schizophrenia. It has therefore become a key region for studies on the disabling cognitive dysfunction commonly observed in patients with schizophrenia. LÄS MER

  3. 2. Episodic memory in the human prefrontal cortex

    Författare :Johan Sandblom; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This thesis consisting of five papers examines the relationship between haemodynamic activation in the prefrontal cortex with episodic memory function in the healthy human brain. Brain function is measured with positron emission tomography (PET) and functional magnetic resonance imaging (FMRI) and episodic memory for words as well as visuo-spatial material is examined. LÄS MER

  4. 3. Modulation of prefrontal glutamatergic transmission and 'atypicality' of antipsychotic drugs

    Författare :Åsa Konradsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The glutamate hypothesis of schizophrenia suggests a relationship between hypoactive NMDA receptor-mediated glutamatergic transmission and the pathophysiology of schizophrenia. Previous results have demonstrated that atypical (e.g. clozapine, risperidone, and olanzapine), but not typical (e. LÄS MER

  5. 4. Mechanism of action of antipsychotic drugs : focus on the nucleus accumbens and the prefronta cortex : an experimental study

    Författare :Monica M Marcus; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Schizophrenia; antipsychotic drug; nucleus accumbens shell; nucleus accumbens core; prefrontal cortex; dopamine; 5-11T2A receptor; alpha1 adrenoceptor; C12 adrenoceptor; glutamate; nicotine.;

    Sammanfattning : Antipsychotic drugs have been classified as typical or atypical. To achieve an effective antipsychotic effect with typical antipsychotic drugs, e.g. haloperidol, a dopamine D2 receptor blockade of about 70% seems necessary. LÄS MER

  7. 5. The phencyclidine model of schizophrenia : dysregulation of brain dopamine systems induced by NMDA receptor antagonists

    Författare :Jan M Mathé; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :phencyclidine; MK-801; CNQX; prazosin; tetrodotoxin; dopamine; neurotensin; ventral tegmental area; nucleus accumbens; medial prefrontal cortex;

    Sammanfattning : Non-competitive NMDA receptor antagonists, such as phencyclidine (PCP) and dizocilpine (MK-801) can even acutely induce a drug induced psychotic state which closely resembles schizophrenia. The midbrain dopamine (DA) neurons, which originate in the ventral tegmental area (VTA), are involved in motivational, attentional and cognitive processes, and have also been profoundly implicated in schizophrenia. LÄS MER