Sökning: "low oxygen tension"

Visar resultat 1 - 5 av 38 avhandlingar innehållade orden low oxygen tension.

  1. 1. SOD1 misfolding and aggregation in ALS : in the light of conformation-specific antibodies

    Författare :Manuela Lehmann; Jonathan D. Gilthorpe; Stefan L. Marklund; Thomas Brännström; Ulrika Nordström; Elizabeth Fisher; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS; antibodies; SOD1; disordered SOD1; patient-derived models; low oxygen tension; Immunotherapy;

    Sammanfattning : Mutations in the superoxide dismutase 1 (SOD1) gene are linked to the progressive neurodegenerative disease amyotrophic lateral sclerosis (ALS). ALS-associated mutations affect the stability of the SOD1 protein and promote its unfolding. As a consequence, disordered SOD1 species can misfold and accumulate into insoluble aggregates. LÄS MER

  3. 2. Hyaluronan and Renal Fluid Handling : Studies during Normal and Pathological Conditions of Renal Function

    Författare :Viktoria Göransson; Mats Rundgren; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; CD44; gerbils; hyaluronan; ischemia-reperfusion; kidney; osmolality; oxygen tension; rat; renomedullary interstitial cells; water; Cellbiologi; Cell biology; Cellbiologi; Physiology; fysiologi;

    Sammanfattning : The kidney is the major organ responsible for the regulation of the composition and volume of the body fluids, which is essential for homeostasis. The glycosaminoglycan hyaluronan (HA), with extreme water-binding capacity, is present in the interstitium of the kidney with a heterogenous distribution. LÄS MER

  4. 3. Using patient-derived cell models to investigate the role of misfolded SOD1 in ALS

    Författare :Elin Forsgren; Jonathan Gilthorpe; Stefan Marklund; Peter Andersen; Thomas Brännström; Ulrika Nordström; Séverine Boillée; Umeå universitet; []
    Nyckelord :ALS; SOD1; patient-derived models; induced pluripotent stem cells; motor neurons; astrocytes; 20S proteasome low oxygen tension; misfolded SOD1; Neurology; neurologi;

    Sammanfattning : Protein misfolding and aggregation underlie several neurodegenerative proteinopathies including amyotrophic lateral sclerosis (ALS). Superoxide dismutase 1 (SOD1) was the first gene found to be associated with familial ALS. LÄS MER

  5. 4. On the pathophysiology of idiopathic adult hydrosephalus syndrome : energy metabolism, protein patterns, and intracranial pressure

    Författare :Aina Ågren Wilsson; Per Enblad; Umeå universitet; []
    Nyckelord :hydrocephalus; biochemical markers; microdialysis; cerebrospinal fluid; B waves; brain tissue oxygen tension; Neurology; neurologi;

    Sammanfattning : The symptoms in Idiopathic Adult Hydrocephalus Syndrome (IAHS) – gait disturbance, incontinence, and cognitive deficit – correlate anatomically to neuronal dysfunction in periventricular white matter. The pathophysiology is considered to include a cerebrospinal fluid (CSF) hydrodynamic disturbance, including pressure oscillations (“B waves”), in combination with cerebrovascular disease. LÄS MER

  7. 5. A Study of Parameters and Properties Influencing the Size, Morphology and Oxygen Content of Water Atomized Metal Powders

    Författare :Fredrik Persson; Pär Jönsson; Christopher Neil Hulme; Lauri Holappa; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Teknisk materialvetenskap; Materials Science and Engineering;

    Sammanfattning : The production of metal powders by water atomization is a well-established process, which can be used to produce a wide range of particle sizes for different applications. In general, there is a lack of detailed knowledge about what process parameters that affect the powder properties for water atomized metal powders. LÄS MER