Sökning: "long-chain acyl-CoA"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden long-chain acyl-CoA.

  1. 1. Acyl-CoA thioesterases : auxiliary enzymes in peroxisomal lipid metabolism

    Författare :Maria A K Westin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Peroxisomes are small organelles essential for life, which carry out a variety of functions mostly related to lipid metabolism, including α- and β-oxidation as well as the first steps of plasmalogen biosynthesis. Peroxisomal β-oxidation metabolizes many different lipids including very long-chain fatty acids, dicarboxylic fatty acids, branched-chain fatty acids, eicosanoids and certain xenobiotic fatty acids. LÄS MER

  3. 2. Structural and Functional Studies of Membrane Proteins : From Characterisation of a Fatty Acyl-CoA Synthetase to the Discovery of Superoxide Oxidase

    Författare :Camilla A. K. Lundgren; Martin Högbom; James Imlay; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; biokemi;

    Sammanfattning : This thesis is divided into three parts; the first part describes a method for efficient screening of membrane proteins for crystallography. By utilising the properties of a folding reporter GFP it is possible to quickly and accurately screen the stability of a protein in a range of conditions without full purification. LÄS MER

  4. 3. Esterification of long-chain fatty acids to cholesterol and ethanol : role of acyltransferases and carboxylesterases

    Författare :Margareta A Diczfalusy; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The aim of the present thesis was to investigate esterification of long-chain fatty acids to cholesterol and ethanol. The esterification products, cholesteryl esters and ethyl esters, may under certain circumstances accumulate in some cell types and tissues and cause pathological changes. LÄS MER

  5. 4. Synthesis of jojoba-like wax esters in metabolically engineered strains of Saccharomyces cerevisiae

    Författare :Leonie Wenning; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Saccharomyces cerevisiae; very long-chain monounsaturated fatty alcohols; very long-chain monounsaturated fatty acids; jojoba-like wax esters;

    Sammanfattning : Yeast has a long-standing tradition in human history as a production organism of choice. Besides being used for the production of fermented products like bread or beer, it has also been extensively explored for the production of proteins and chemicals. LÄS MER

  7. 5. Metabolic signals and the ATP-sensitive potassium channel in the pancreatic beta-cell

    Författare :Robert Bränström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ATP-regulated K channel; pancreatic [beta]-cell oscillations; [alpha]-ketoisocaproate; long chain acyl-CoA esters; Kir6.2 SUR1 structure-function.;

    Sammanfattning : ATP-sensitive K+ (KATP) channels are widely distributed in a variety of tissues and cell types. KATP channels are comprised of two subunits, a pore forming subunit (Kir6.x) and a regulatory sulfonylurea receptor (SURx). Both subunits are required for fully functional channels. LÄS MER