Sökning: "levodopa"

Visar resultat 21 - 25 av 30 avhandlingar innehållade ordet levodopa.

  1. 21. Intrinsic and extrinsic factors controlling the differentiation of human midbrain progenitor cells

    Författare :Nicolaj Christophersen; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; neurotrophic factors; Parkinson s disease; microarray; dopaminergic; Embryonic stem cells; neural stem cells;

    Sammanfattning : Parkinson's disease (PD) is a common neurodegenerative disorder characterized by motor deficits. Levodopa treatment provides marked symptomatic relief. However, within 5-10 years after the start of Levodopa treatment, most PD patients display a gradual loss of drug efficacy. LÄS MER

  3. 22. Peripheral neuropathy and altered cobalamin metabolism in Parkinson's disease and other movement disorders

    Författare :Mattias Andréasson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Peripheral neuropathy is a disorder of the peripheral nervous system (PNS) that may carry different underlying aetiologies. Studies have suggested PNS involvement may be prevalent in neurological diseases that traditionally have been regarded primarily as disorders of the central nervous system (CNS), including the neurodegenerative disorder Parkinson’s disease (PD). LÄS MER

  4. 23. Functional regulation of the dopaminergic system in vivo : Experimental and clinical studies with positron emission tomography

    Författare :Richard Torstensson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; analytisk farmaceutisk kemi; Analytical Pharmaceutical Chemistry;

    Sammanfattning : Positron emission tomography (PET) is a non-invasive imaging technique used to quantitate the kinetics of a radiotracer in such physiological processes as receptor binding and enzyme activity. Radiolabelled L-DOPA has previously been used as a tracer for the dopaminergic system. LÄS MER

  5. 24. Studies on eye movements in Parkinson's disease

    Författare :Panagiota Tsitsi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Heterogeneity in Parkinson’s Disease (PD) phenotype and genotype is probably the main reason why, despite the abundance of biomarkers, we still lack a robust method for diagnosis and prognosis, besides clinical evaluation. Subjective changes in vision and objective measures in eye movements have been extensively studied, but the results are mainly used to better understand the pathophysiology of PD and are not integrated into the clinical praxis. LÄS MER

  7. 25. Astrocytes as Cellular Vehicles in Ex Vivo Gene Therapy Studies to the Rat Brain

    Författare :Cecilia Ericson; CNS Genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; Lentivirus; Transplantation; CNS; Astrocytes;

    Sammanfattning : Neurodegenerative disorders are characterized by a progressive cell-death in the brain, and loss of different functions in the patient. Today, there are no cures for any of the various diseases. Parkinson's disease is a neurodegenerative disorder with a prevalence of 0. LÄS MER