Sökning: "hollow fiber"

Visar resultat 6 - 10 av 26 avhandlingar innehållade orden hollow fiber.

1. 6. High cell density perfusion process development for antibody producing Chinese Hamster Ovary cells

   Författare :Ye Zhang; Vincent Bulone; Veronique Chotteau; Carl-Fredrik Mandenius; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; WAVE Bioreactor; Cellbag; ATF; TFF; hollow fiber; CSPR; CellTank; SUB; single-use-bioreactor; disposable; perfusion rate; Biotechnology; Bioteknologi;

   Sammanfattning : Perfusion operation mode is currently under fast expansion in mammalian cell based manufacturing of biopharmaceuticals, not only for labile drug protein but also for stable proteins such as monoclonal antibodies (mAbs). Perfusion mode can advantageously offer a stable cell environment, long-term production with high productivity and consistent product quality. LÄS MER

3. 7. Light Scattering in Fiber-based Materials : a foundation for characterization of structural properties

   Författare :Tomas Linder; Stefan Andersson-Engels; Luleå tekniska universitet; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Industriell elektronik; Industrial Electronics;

   Sammanfattning : Deeper knowledge of light propagation in fiber-based materials is fundamental in order to understand their optical appearance as well as for industrial applications. Light scattering measurements are appropriate in handling dynamic industrial environments and can provide information regarding structural properties. LÄS MER

4. 8. Application of new methodology for preclinical development of anticancer drugs : With special focus on camptothecin derivatives and the cyanoguanidine CHS 828

   Författare :Elin Jonsson; Uppsala universitet; []
   Nyckelord :Medical sciences; drug development; hollow-fiber model; FMCA; human tumour cell; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

   Sammanfattning : This work describes the development and evaluation of new methods for preclinical anticancer drug development. The methods were specifically applied to study camptothecin analogues and the new compound CHS 828 (N-(4-chlorophenoxyhexyl)-N'-cyano-N"-4-pyridylguanidine) currently in early clinical trials. LÄS MER

5. 9. Analyses of Dose-Response and Mechanistic Action of Different Anti-Cancer Drugs for Neuroendocrine Tumor Cell Lines

   Författare :Dhana E Larsson; Dan Granberg; Sadia Hassan; Kjell Öberg; Jens F Rehfeld; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer drugs; Screening; Hollow Fiber model; Apoptosis; Oncology; Onkologi;

   Sammanfattning : Cancer is a disease with poor response rates on available treatments. Problems with resistance and intolerance against cancer drugs are major reasons for failure of the drugs. The need to discover new cancer drugs is important. In this thesis screening of new cancer drugs and evaluation of their mechanism of action are discussed. LÄS MER

7. 10. Development of Techniques to Produce Nickel Coated Composite Materials as well as Hollow Nickel Fibres and Kinetic Study of the Process Involved

   Författare :Fan Li; Sichen Du; Ioannis Arvanitidis; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Nickel; Chemical plating; Kinetics; Model; Hollow nickel fibres; Thermal decomposition; Materials science; Teknisk materialvetenskap;

   Sammanfattning : The present thesis was mainly to study the preparation of nickel composite materials by chemical plating process. Nickel coated boron nitride particles, nickel coated spherical silica particles and nickel viscose composite fibres were prepared. Both experiment and model development were carried out to study the kinetics of the processes. LÄS MER