Sökning: "WAVE Bioreactor"

Hittade 2 avhandlingar innehållade orden WAVE Bioreactor.

  1. 1. High cell density perfusion process development for antibody producing Chinese Hamster Ovary cells

    Författare :Ye Zhang; Vincent Bulone; Veronique Chotteau; Carl-Fredrik Mandenius; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; WAVE Bioreactor; Cellbag; ATF; TFF; hollow fiber; CSPR; CellTank; SUB; single-use-bioreactor; disposable; perfusion rate; Biotechnology; Bioteknologi;

    Sammanfattning : Perfusion operation mode is currently under fast expansion in mammalian cell based manufacturing of biopharmaceuticals, not only for labile drug protein but also for stable proteins such as monoclonal antibodies (mAbs). Perfusion mode can advantageously offer a stable cell environment, long-term production with high productivity and consistent product quality. LÄS MER

  3. 2. Hydrodynamics considerations in cells systems from ocean flow to perfusion cultivation process

    Författare :Caijuan Zhan; Véronique Chotteau; Jeffrey Chalmers; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Microorganism; cells; hydrodynamics; turbulence; numerical simulation; CFD; Resonance; Wave bioreactor; ATF; TFF; perfusion; design feeding strategy; Bioteknologi; Biotechnology;

    Sammanfattning : Microorganisms and animal cells are grown surrounded by fluid, which is providing them with nutrients and removing their waste products. In nature and industry processes, cells/microbes can be subject to aggressive environments, such as turbulent flow or shear flow. LÄS MER