Sökning: "hepatocyte nuclear factor"
Visar resultat 1 - 5 av 13 avhandlingar innehållade orden hepatocyte nuclear factor.
1. New Roles of Filamins in Cell Signaling, Transcription and Organ Development
Sammanfattning : Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin networks and link them to cellular membranes. They integrate cell architectural and signaling functions and are essential for cell locomotion and development. LÄS MER
2. Mechanistic analyses of hepatocyte plasticity
Sammanfattning : Adult hepatocytes are highly plastic cells which have a molecular toolbox for efficient regeneration. Yet, end stage liver diseases are becoming an increasing clinical burden. LÄS MER
3. Search for MODY and Type 2 diabetes genes
Sammanfattning : Diabetes is a heterogeneous disease influenced by both environmental and genetic factors. Maturity-onset diabetes of the young (MODY) is considered as a subform of Type 2 diabetes, which is inherited in an autosomal dominant fashion and expressed at childhood or early adult life. LÄS MER
4. Growth hormone regulation of LFABP and PPARa. Genes involved in hepatic lipid metabolism
Sammanfattning : Growth hormone (GH) is known to have several important effects in the control of metabolism. The aim of these studies was to investigate how GH regulates genes involved in fatty acid transport and metabolism in the liver and the interaction between GH and fatty acids in this regulation. LÄS MER
5. Studies on function and regulation of the transcription factor C/EBPalpha
Sammanfattning : The transcription factor C/EBPalpha was originally identified as a protein involved in hepatocyte-specific gene regulation. Later, it has been demonstrated that C/EBPalpha is expressed in several other tissues, mainly in adipose cells, lung, intestine, skin and in myeloid cells. LÄS MER