Sökning: "Smad2 protein"
Visar resultat 1 - 5 av 19 avhandlingar innehållade orden Smad2 protein.
1. New Roles of Filamins in Cell Signaling, Transcription and Organ Development
Sammanfattning : Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin networks and link them to cellular membranes. They integrate cell architectural and signaling functions and are essential for cell locomotion and development. LÄS MER
2. Protein Acetylation – A Multifunctional Regulator of TGF-β Signaling
Sammanfattning : Transforming growth factor β (TGF-β) is a member of a large family of cytokines that regulate many crucial events in cells, including proliferation, differentiation, migration and apoptosis. Deregulated TGF-β signaling is associated with various forms of cancers and developmental disorders. LÄS MER
3. Proteome profiling of human breast cancer
Sammanfattning : Breast cancer (BC) takes thousands of woman’s lives yearly. Several factors have been found to influence initiation and development of breast cancer, and to affect prognosis and treatment of this disease. LÄS MER
4. Improvements and Applications of in situ Proximity Ligation Assays
Sammanfattning : The cells building up the human body is in constant communication with each other. This communication is done through large complex networks of signaling pathways for inter- and intracellular signal transduction. The signaling activity regulates many important processes, for example cell death, proliferation and differentiation. LÄS MER
5. Cross-regulation between TGFβ/BMP Signalling and the metabolic LKB1 pathway
Sammanfattning : Cell signalling determines physiological responses to many cellular stimuli and environmental changes. The transforming growth factor-beta (TGFβ)/bone morphogenetic protein (BMP) signalling pathways begin by binding of ligand to the heterodimeric receptor complex, followed by activation of Smads that translocate to the nucleus to regulate transcription of genes that further mediate cellular physiology. LÄS MER