Sökning: "RAS mutations"

Visar resultat 1 - 5 av 48 avhandlingar innehållade orden RAS mutations.

  1. 1. Prognostic and Predictive Factors in Metastatic Colorectal Cancer

    Författare :Emerik Österlund; Tobias Sjöblom; Bengt Glimelius; Peter Nygren; Torben Frøstrup Hansen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; metastatic colorectal cancer; RAS mutations; BRAF mutations; biomarkers; outcome;

    Sammanfattning : The outcome for metastatic colorectal cancer (mCRC) patients has improved substantially in recent decades. This has chiefly been observed in study populations, and predominantly in left-sided primary tumours, which is why we wanted to study if and how survival has improved in the background population. LÄS MER

  3. 2. Cell fate specification by Ras-mediated cell signalling in C. elegans

    Författare :Teresa Tiensuu; Simon Tuck; Benjamin Podbilewicz; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; cell signalling; Ras; vulva precursor cell; lin-25; sur-2; lin-1; cell fate specification; Mediator; vulva induction; transcriptional regulation; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

    Sammanfattning : Induction of vulval fates in the C. elegans hermaphrodite is mediated by a conserved RTK/Ras/MAP kinase signalling pathway, in which the core components can be placed into a linear genetic and biochemical pathway. However, the events that occur downstream of this pathway are not yet well understood. LÄS MER

  4. 3. Role of FLT3 in Acute Myeloid Leukemia: Molecular mechanisms and Therapeutic opportunities

    Författare :Sausan Moharram; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LEUKEMIA; AML; Mutations; FLT3; Signlaing;

    Sammanfattning : Acute myeloid leukemia (AML) is a highly heterogeneous blood disease which is characterized by different mutations and chromosomal rearrangements. Nearly 60% of genetic alterations have been found in AML patients involve in signaling pathways including signaling of tyrosine kinase receptor FLT3. LÄS MER

  5. 4. RAS-MAPK syndromes - a Clinical and Molecular Investigation

    Författare :Anna-Maja Nyström; Marie-Louise Bondeson; Göran Annerén; Anna Wedell; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; RAS-MAPK syndromes; Noonan syndrome; Neurofibromatosis type I; cardio-facio-cutaneous syndrome; mutation; multiplex ligation-dependent probe amplification; gene; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; Klinisk genetik; Clinical Genetics;

    Sammanfattning : The RAS-MAPK syndromes are a group of clinically and genetically related disorders, characterized by cardiac defects, facial dysmorphism, cutaneous abnormalities and neurocognitive impairment. The pathogenesis is dysregulation of the RAS-MAPK pathway, and several genes within the pathway are involved. LÄS MER

  7. 5. The Importance of Isoprenylation and Nf1 Deficiency in K-RAS-induced Cancer

    Författare :Anna-Karin Sjögren; Göteborgs universitet; []
    Nyckelord :FTase; GGTase-I; isoprenylation; K-RAS; NF1; CAAX proteins; lung cancer; AML;

    Sammanfattning : The RAS and RHO family proteins contribute to tumorigenesis and metastasis and belong to a family of so called CAAX proteins. The membrane targeting and proper function of CAAX proteins are dependent on posttranslational isoprenylation by farnesyltransferase (FTase) or geranylgeranyltransferase type I (GGTase-I). LÄS MER