Sökning: "hepatitis C virus"
Visar resultat 1 - 5 av 104 avhandlingar innehållade orden hepatitis C virus.
1. Hepatitis C virus infection : a nationwide study of associated morbidity and mortality
Sammanfattning : The hepatitis C virus (HCV) was characterised in 1989. HCV was transmitted through transfusion of blood/blood products, but injection drug use is now the most common route of transmission. LÄS MER
2. GB virus C/hepatitis G virus infection: clinical, histological and epidemiological aspects
Sammanfattning : GBV-C/HGV is a blood-borne virus related to the hepatitis C virus. We studied GBV-C/HGV infection in different populations, its transmission, and its association with liver disease. GBV-C/HGV viraemia was detected by PCR in 19/576 blood donors. Donors with normal and elevated ALT levels had similar rates of viraemia (1. LÄS MER
3. Design and Synthesis of Inhibitors Targeting the Hepatitis C Virus NS3 Protease : Focus on C-Terminal Acyl Sulfonamides
Sammanfattning : Hepatitis C is a global health problem that affects approximately 120–180 million people. This viral infection causes serious liver diseases and the therapy available suffers from low efficiency and severe side effects. Consequently, there is a huge unmet medical need for new therapeutic agents to combat the hepatitis C virus (HCV). LÄS MER
4. Hepatitis C virus. Aspects on natural history, antibody response, and viral quantification
Sammanfattning : Hepatitis C virus (HCV) is the major cause of parenterally transmitted non-A, non-B hepatitis, and is associated with chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Despite the screening of blood products nosocomial spread of HCV continues to occur. LÄS MER
5. Design and Synthesis of Hepatitis C Virus NS3 Protease Inhibitors : Targeting Different Genotypes and Drug-Resistant Variants
Sammanfattning : Since the first approved hepatitis C virus (HCV) NS3 protease inhibitors in 2011, numerous direct acting antivirals (DAAs) have reached late stages of clinical trials. Today, several combination therapies, based on different DAAs, with or without the need of pegylated interferon-α injection, are available for chronic HCV infections. LÄS MER