Sökning: "helix-loop-helix"

Visar resultat 1 - 5 av 50 avhandlingar innehållade ordet helix-loop-helix.

  1. 1. Cooperative Reactive Sites in Designed Helix-Loop-Helix Polypeptide Catalysts

    Författare :Jonas W. Nilsson; Paolo Scrimin; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Designed polypeptides, which fold into helix-loop-helix motifs and dimerise to four-helix bundles have been used as scaffolds for the introduction of catalytic activity for the hydrolysis of p-nitrophenyl esters. The reactive sites were based on the reactivity of histidine, and two His residues separated by four residues in the sequence was shown to be the minimal reactive site for the efficient hydrolysis of nitrophenyl esters. LÄS MER

  3. 2. Calcium regulation and functions of basic Helix-Loop-Helix transcription factors

    Författare :Juha Saarikettu; Thomas Grundström; Dan Holmberg; Mikael Sigvardsson; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; calcium; calmodulin; calretinin; transcription; bHLH; E-protein; E2-2; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : The members of the ubiquitously expressed E-protein subfamily of basic Helix-Loop-Helix (bHLH) transcription factors, E12/E47, SEF2-1 and HEB, have important roles as regulators of gene expression in various differentiation processes, including lymphocyte development and myogenesis. In myogenesis, E-proteins are proposed to function as obligate heterodimer partners for members of the MyoD family of muscle-specific bHLH transcription factors. LÄS MER

  4. 3. Regulation and functions of basic helix-loop-helix transcription factors in neuroblastoma cells

    Författare :Paula Persson; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Cytology; Id; Olf EBF; ubiquilin-1; HASH-1; bHLH; Neuroblastoma; neuronal differentiation; cancer; onkologi; cancerology; Cytologi;

    Sammanfattning : Neuroblastoma is a childhood tumor derived from primordial neural crest cells. The tumor cells exhibit a phenotype similar to that of developing neuroblasts, which indicates that the tumor arises due to perturbed differentiation of the sympathetic nervous system. LÄS MER

  5. 4. Polypeptide-Based Nanoscale Materials

    Författare :Daniel Aili; Bo Liedberg; Karin Enander; Molly Stevens; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gold nanoparticle; polypeptide; helix-loop-helix; four-helix bundle; self-assembly; folding; Chemistry; Kemi;

    Sammanfattning : Self-assembly has emerged as a promising technique for fabrication of novel hybrid materials and nanostructures. The work presented in this thesis has been focused on developing nanoscale materials based on synthetic de novo designed polypeptides. LÄS MER

  7. 5. Cell cycle genes in chondrosarcoma. Involvement of the Id1 and p16 pathways

    Författare :Julia Asp; Göteborgs universitet; []
    Nyckelord :chondrosarcoma; articular chondrocytes; cell cycle; p16; Id1; helix-loop-helix;

    Sammanfattning : Chondrosarcoma is a malignant, cartilaginous tumour arising from bone. The wide variationin morphology, behaviour and clinical outcome raise the question whether chondrosarcomasare several different but closely related tumours rather than a single entity. LÄS MER