Sökning: "glycation"

Visar resultat 1 - 5 av 30 avhandlingar innehållade ordet glycation.

1. 1. Apolipoprotein A-I in glucose metabolism and amyloidosis

   Författare :Oktawia Nilsson; Medicinsk proteinvetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amyloidosis; Apolipoprotein A-I; beta cell; cardiovascular disease; cholesterol efflux; diabetes; glucose metabolism; glycation; high-density lipoprotein; insulin secretion;

   Sammanfattning : The role of Apolipoprotein A-I (ApoA-I), the main protein component of HDL, in cholesterol transport and metabolism is well known and has been studied for more than four decades. More recently, ApoA-I protein has been shown to also have a positive role in glucose control by both stimulation of glucose uptake by muscles and by increasing glucose-stimulated pancreatic insulin secretion. LÄS MER

3. 2. Teratogenic Predisposition in Diabetic Rat Pregnancy

   Författare :Andreas Ejdesjö; Ulf J Eriksson; Parri Wentzel; Niklas Nordquist; Gernot Desoye; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetes; malformations; teratogenic; advanced glycation end products; AGE; RAGE; oxidative stress; ROS; gene expression; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : Pre-gestational diabetes increases the risk of congenital malformation in the offspring and both morbidity and mortality in the diabetic mother and her offspring. During pregnancy, high glucose levels act as a teratogen through several cellular and biochemical pathways and increased production of reactive oxygen species (ROS) has a central role in diabetic embryopathy. LÄS MER

4. 3. Protein Damage Control during Embryonic Stem Cell Differentiation: Role of the Proteasome

   Författare :Malin Hernebring; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Embryonic Stem Cells; Proteasome; Protein Carbonylation; Advanced Glycation End products; Cell Differentiation; Oxidative stress; Aging; RNAi;

   Sammanfattning : During the lifespan of organisms ranging from yeast to humans, there is an accumulation of macromolecular damage. However, these organisms produce youthful progeny with low damage levels. This thesis focuses on how this is accomplished. LÄS MER

5. 4. Glucose degradation products in patients on hemodialysis : interventional studies

   Författare :Bernd Ramsauer; Bernd Stegmayr; Henrik Hadimeri; Bengt Lindholm; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hemodialysis; advanced glycation end products; skin autofluorescence; plasma autofluorescence; glucose degradation products;

   Sammanfattning : Hemodialysis (HD) is the most frequently used treatment for end-stage renal disease. Despite all efforts to improve the outcomes, the mortality of patients on HD is still high, and this especially is related to cardiovascular diseases (CVD). LÄS MER

7. 5. The inflammatory and immunogenic properties of the receptor for advanced glycation end products and its ligand, high mobility group box chromosomal protein 1

   Författare :Rille Pullerits; Göteborgs universitet; []
   Nyckelord :HMGB1; sRAGE; rheumatoid arthritis; inflammation; cytokines;

   Sammanfattning : Rheumatoid arthritis (RA) is a chronic systemic inflammatory joint disease, the pathogenesis of which is complex, involving a wide range of molecules. High mobility group box chromosomal protein 1 (HMGB1) is a nuclear protein recently recognised as a pro-inflammatory cytokine which levels are increased in RA patients. LÄS MER