Sökning: "Parri Wentzel"

Hittade 5 avhandlingar innehållade orden Parri Wentzel.

  1. 1. Altered embryonic environment and congenital malformations in diabetic pregnancy

    Författare :Parri Wentzel; Uppsala universitet; []
    Nyckelord :Abnormalities *etiology prevention control; Animals; Diabetes Mellitus; Experimental *pathology; Dietary Supplements; Female; Folic Acid *therapeutic use; Glucose *toxicity; Neural Tube Defects etiology prevention control; Pregnancy; Pregnancy in Diabetics *physiopathology; RNA genetics isolation purification; Rats; Research Support; Non-U.S. Gov t; Tail abnormalities embryology;

    Sammanfattning : .... LÄS MER

  3. 2. Developmental disturbances of the embryo in diabetic pregnancy

    Författare :Parri Wentzel; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; diabetes; pregnancy; embryo; malformation; glucose; ROS; SOD; NAC; prosta- glandin; COX; COX inhibitor; gene expression; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : Maternal diabetes during pregnancy constitutes an increased risk for congenital malformation in the offspring. Previous studies have suggested that diabetic embryopathy is associated with an excess of reactive oxygen species (ROS) as well as with a disturbance of prostaglandin (PG) metabolism. LÄS MER

  4. 3. Genetic predisposition for malformations in diabetic rat pregnancy

    Författare :Andreas Ejdesjö; Ulf J Eriksson; Parri Wentzel; Ted Ebendal; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medical cell biology; Medicinsk cellbiologi;

    Sammanfattning : .... LÄS MER

  5. 4. Teratogenic Predisposition in Diabetic Rat Pregnancy

    Författare :Andreas Ejdesjö; Ulf J Eriksson; Parri Wentzel; Niklas Nordquist; Gernot Desoye; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetes; malformations; teratogenic; advanced glycation end products; AGE; RAGE; oxidative stress; ROS; gene expression; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Pre-gestational diabetes increases the risk of congenital malformation in the offspring and both morbidity and mortality in the diabetic mother and her offspring. During pregnancy, high glucose levels act as a teratogen through several cellular and biochemical pathways and increased production of reactive oxygen species (ROS) has a central role in diabetic embryopathy. LÄS MER

  7. 5. Teratogenicity Involved in Experimental Diabetic Pregnancy

    Författare :Mattias Gäreskog; Parri Wentzel; Ulf Eriksson; Jonas Cederberg; Kari Teramo; Uppsala universitet; []
    Nyckelord :Cell biology; Diabetes; Pregnancy; PKC; Apoptosis; Rat; Embryopathy; Vitamin E; Folic acid; CHC; NAC; Cellbiologi;

    Sammanfattning : Maternal diabetes is associated with increased risk of growth disturbances and congenital malformations. The malformations rate in the offspring of diabetic mothers is 2-3 fold higher compared to infants of nondiabetic mothers. LÄS MER