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1. 1. The calcitonin gene family of peptides : receptor expression and effects on bone cells

   Författare :Susanne Granholm; Ulf Lerner; Pernilla Lundberg; Göran Andersson; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; CT family of peptides; osteoclast differentiation; bone resorption; CTR; CRLR; RAMPs; Cell biology; Cellbiologi;

   Sammanfattning : The calcitonin gene family of peptides consists of calcitonin (CT), two calcitonin gene related peptides (α-CGRP, β-CGRP), adrenomedullin (ADM), amylin (AMY), three calcitonin receptor activating peptides (CRSP1-3) and intermedin/adrenomedullin2 (IMD). These peptides bind to one of two G protein -coupled receptors, the calcitonin receptor (CTR) or the calcitonin receptor-like receptor (CRLR). LÄS MER

3. 2. Evolution of Vertebrate Endocrine and Neuronal Gene Families : Focus on Pituitary and Retina

   Författare :Daniel Ocampo Daza; Dan Larhammar; Marc Robinson-Rechavi; Uppsala universitet; []
   Nyckelord :phylogenetics; evolution; molecular evolution; gene family evolution; genome duplication; gene duplication; oxytocin receptor; vasopressin receptor; visual opsin; transducin; growth hormone; prolactin; somatolactin; growth hormone receptor; prolactin receptor; somatostatin receptor; SSTR; IGFBP; evolution; molekylär evolution; fylogeni;

   Sammanfattning : The duplication of genes followed by selection is perhaps the most prominent way in which molecular biological systems gain multiplicity, diversity and functional complexity in evolution. Whole genome duplications (WGDs) therefore have the potential of generating an extraordinary amount of evolutionary innovation. LÄS MER

4. 3. A Genetic Survey of the Pathogenic Parasite Trypanosoma cruzi

   Författare :Anh-Nhi Tran; Lena Åslund; John Kelly; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; Trypanosoma cruzi; Chagas ; gene discovery; EST; sequencing; DGC3; repeats; gene family; CL Brener; trypanothione synthetase; TcTRS locus; alleles; polymorphism; RNA-binding protein; TcPTB; stage-specific expression; Genetik; Genetics; Genetik; medicinsk genetik; Medical Genetics;

   Sammanfattning : Trypanosoma cruzi, the causative agent of Chagas´ disease, is an evolutionarily ancient species with distinct biological and immunological characteristics. A fundamental understanding of the basic biology of the parasite is necessary in order to develop reliable therapeutic and prophylactic agents against T. cruzi. We have, as a part of the T. LÄS MER

5. 4. Topics in Human Gene Mapping

   Författare :Azra Kurbasic; Matematisk statistik; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; actuarial mathematics; Statistik; programming; Statistics; Mathematics; Naturvetenskap; Natural science; hidden Markov model; linkage analysis; Human genome; disease gene; programmering; aktuariematematik; operationsanalys; operations research; Matematik;

   Sammanfattning : This thesis is interdisciplinary between Mathematical Statistics, Genetics, and Medicine. It mainly consists of topics in mathematical modelling of the correlation of inheritance of genes and disease in a family, a method called linkage analysis. It is organized as follows. LÄS MER

7. 5. Functional Diversification among MADS-Box Genes and the Evolution of Conifer Seed Cone Development

   Författare :Erika Groth; Peter Engström; Karolina Tandre; Tom Gerats; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; conifer; seed cone; evo-devo; morphology; plant development; plant evolution; gene family; gene evolution; AGAMOUS; MADS-box; transcription factor; Picea; Cryptomeria; Thujopsis; Juniperus; Biology; Biologi; Biologi med inriktning mot fysiologisk botanik; Biology with specialization in Physiological Botany;

   Sammanfattning : MADS-box genes are important regulators of reproductive development in seed plants, including both flowering plants and conifers. In this thesis the evolution of the AGAMOUS subfamily of MADS-box genes, and what the ancestral function of this group of genes might have been in the early seed plants about 300 million years ago, was addressed by the discovery of two novel conifer genes, both basal to all previously known AGAMOUS subfamily genes. LÄS MER