Sökning: "gene duplication"

Visar resultat 1 - 5 av 112 avhandlingar innehållade orden gene duplication.

  1. 1. Evolution of Vertebrate Endocrine and Neuronal Gene Families : Focus on Pituitary and Retina

    Författare :Daniel Ocampo Daza; Dan Larhammar; Marc Robinson-Rechavi; Uppsala universitet; []
    Nyckelord :phylogenetics; evolution; molecular evolution; gene family evolution; genome duplication; gene duplication; oxytocin receptor; vasopressin receptor; visual opsin; transducin; growth hormone; prolactin; somatolactin; growth hormone receptor; prolactin receptor; somatostatin receptor; SSTR; IGFBP; evolution; molekylär evolution; fylogeni;

    Sammanfattning : The duplication of genes followed by selection is perhaps the most prominent way in which molecular biological systems gain multiplicity, diversity and functional complexity in evolution. Whole genome duplications (WGDs) therefore have the potential of generating an extraordinary amount of evolutionary innovation. LÄS MER

  3. 2. Evolutionary Analysis of the Insulin-Relaxin Gene Family from the Perspective of Gene and Genome Duplication Events

    Författare :Robert Piotr Olinski; Finn Hallböök; Mike Thorndyke; Pierre Pontarotti; Uppsala universitet; []
    Nyckelord :Neurosciences; insulin; relaxin; insulin-like protein; gene duplication; paralogous region; Ciona intestinalis; conserved synteny; ortholog; Drosophila melanogaster; Neurovetenskap;

    Sammanfattning : Paralogs arise by duplications and belong to families. Ten paralogs (insulin; IGF-1 and -2; INSL3-6 and 3-relaxins) constitute the human insulin-relaxin family. The aim of this study was to outline the duplications that gave rise to the vertebrate insulin-relaxin genes and the chromosomal regions in which they reside. LÄS MER

  4. 3. The Carboxyl Ester Lipase Gene. Organization, Evolution and Transcriptional Regulation in Exocrine Pancreas and Mammary Gland

    Författare :Ulf Lidberg; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NF-1; pseudogene; evolution; pancreas; carboxyl ester lipase; regulation; duplication; promoter; enhancer; locus; gene structure; mammary gland;

    Sammanfattning : The carboxyl ester lipase (CEL) is an important enzyme for the intestinal absorption of dietary lipids. In humans the gene is highly expressed in exocrine pancreas and in the lactating mammary gland. It is secreted in an inactive form and becomes activated by bile salts in the intestine. LÄS MER

  5. 4. Probabilistic Modelling of Domain and Gene Evolution

    Författare :Sayyed Auwn Muhammad; Jens Lagergren; Bastien Boussau; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Phylogenetics; Phylogenomics; Evolution; Domain Evolution; Gene tree; Domain tree; Bayesian Inference; Markov Chain Monte Carlo; Homology Inference; Gene families; C2H2 Zinc-Finger; Reelin Protein; Computer Science; Datalogi;

    Sammanfattning : Phylogenetic inference relies heavily on statistical models that have been extended and refined over the past years into complex hierarchical models to capture the intricacies of evolutionary processes. The wealth of information in the form of fully sequenced genomes has led to the development of methods that are used to reconstruct the gene and species evolutionary histories in greater and more accurate detail. LÄS MER

  7. 5. Evolution of the Neuropeptide Y and Opioid Systems and their Genomic Regions

    Författare :Görel Sundström; Dan Larhammar; Manfred Schartl; Uppsala universitet; []
    Nyckelord :neuropeptide Y; opioid; evolution; genome duplication; gene duplication; Hox; SCN; IGFBP; MEDICINE; MEDICIN;

    Sammanfattning : Two whole genome duplications (2R) occurred early in vertebrate evolution. By using combined information from phylogenetic analyses and chromosomal location of genes, this thesis delineates the evolutionary history of two receptor-ligand systems that expanded by these large scale events. LÄS MER